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- W254397992 abstract "Background: The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are widely used for the treatment of hyperlipidemia, and recent in vitro and animal data suggest that statins promote bone formation and increase bone strength. Methods: To determine whether statin use is associated with a reduced risk for fracture, we analyzed statin use and fracture rates in 4 large prospective studies (the Study of Osteoporotic Fractures, the Fracture Intervention Trial, the Heart and Estrogen/Progestin Replacement Study, and the Rotterdam Study). We searched MEDLINEthroughJanuary2002andabstractsfrommajorscientificmeetingsandperformedacumulativemetaanalysisofpublishedandunpublishedobservationalstudies and clinical trials. The meta-analysis included 8 observational studies and 2 clinical trials that reported statin use and documented fracture outcomes. Results: After adjustment for multiple factors, including age, body mass index, and estrogen use, we found a trendtowardfewerhipfractures(relativehazards[RHs], 0.19-0.62)and,toalesserextent,nonspinefractures(RHs, 0.49-0.95) among statin users in each of the 4 prospective studies. The meta-analysis of observational studies was consistent with these findings. The summary odds ratio (OR) for statin use and hip fracture was 0.43 (95% confidenceinterval[CI],0.25-0.75),whereasthatfornonspine fracture was 0.69 (95% CI, 0.55-0.88). The metaanalysis of clinical trial results did not support a protective effect with statin use for hip fracture (summary OR, 0.87;95%CI,0.48-1.58)ornonspinefracture(OR,1.02; 95% CI, 0.83-1.26)." @default.
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- W254397992 date "2004-01-01" @default.
- W254397992 modified "2023-09-24" @default.
- W254397992 title "Results of 4 Prospective Studies and Cumulative Meta-analysis of Observational Studies and Controlled Trials" @default.
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