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- W2544018082 abstract "Many biochemical processes take place on timescales ranging from femto-seconds to seconds. Accordingly, any time-resolved experiment must be matched to the speed of the structural changes of interest. Therefore, the timescale of interest defines the requirements of the X-ray source, instrumentation and data-collection strategy. In this study, a minimalistic approach for in situ crystallization is presented that requires only a few microlitres of sample solution containing a few hundred crystals. It is demonstrated that complete diffraction data sets, merged from multiple crystals, can be recorded within only a few minutes of beamtime and allow high-resolution structural information of high quality to be obtained with a temporal resolution of 40 ms. Global and site-specific radiation damage can be avoided by limiting the maximal dose per crystal to 400 kGy. Moreover, analysis of the data collected at higher doses allows the time-resolved observation of site-specific radiation damage. Therefore, our approach is well suited to observe structural changes and possibly enzymatic reactions in the low-millisecond regime." @default.
- W2544018082 created "2016-11-04" @default.
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- W2544018082 date "2016-10-26" @default.
- W2544018082 modified "2023-09-26" @default.
- W2544018082 title "A multicrystal diffraction data-collection approach for studying structural dynamics with millisecond temporal resolution" @default.
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- W2544018082 doi "https://doi.org/10.1107/s2052252516016304" @default.
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