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- W2544117639 endingPage "3315" @default.
- W2544117639 startingPage "3297" @default.
- W2544117639 abstract "Nucleotide binding oligomerization domain 2 (NOD2), a protein involved in the first line defence mechanism has a pivotal role in innate immunity. Impaired function of this protein is implicated in disorders such as Blau syndrome and Crohn's disease. Since an altered function is linked to protein's structure, we framed a systematic strategy to interpret the structure-function relationship of the protein. Initiated with mutation-based pattern prediction and identified a distant ortholog (DO) of NOD2 from which the intra-residue interaction network was elucidated. The network was used to identify hotspots that serve as critical points to maintain the stable architecture of the protein. Structural comparison of NOD2 domains with a DO revealed the minimal number of intra-protein interactions required by the protein to maintain the structural fold. In addition, the conventional molecular dynamics simulation emphasized the conformational transitions at hot spot residues between native NOD2 domains and its respective mutants (G116R, R42W and R54A) structures. The analysis of intra-protein interactions globally and the displacement of residues locally around the mutational site revealed loss of several critical bonds and residues vital for the protein's function. Conclusively we report, about 10 residues in leucine-rich repeat, 13 residues in NOD and 6 residues in CARD domain are required by the NOD2 to maintain its function. This protocol will help the researchers to achieve for more prospective studies to attest druggable site utility in discovering novel drug candidates." @default.
- W2544117639 created "2016-11-04" @default.
- W2544117639 creator A5044606438 @default.
- W2544117639 creator A5062733579 @default.
- W2544117639 creator A5088386224 @default.
- W2544117639 creator A5091432281 @default.
- W2544117639 date "2016-11-16" @default.
- W2544117639 modified "2023-09-23" @default.
- W2544117639 title "Casting the critical regions in nucleotide binding oligomerization domain 2 protein: a signature mediated structural dynamics approach" @default.
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- W2544117639 doi "https://doi.org/10.1080/07391102.2016.1254116" @default.