FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2544142007> ?p ?o ?g. }

• W2544142007 endingPage "e0165613" @default.
• W2544142007 startingPage "e0165613" @default.
• W2544142007 abstract "Background Chemerin, a novel adipokine, plays a role in the inflammation status of vascular endothelial cells. Hypoxia causes endothelial-cell proliferation, migration, and angiogenesis. This study was aimed at evaluating the protein and mRNA expression of chemerin after exposure of human coronary artery endothelial cells (HCAECs) to hypoxia. Methods and Results Cultured HCAECs underwent hypoxia for different time points. Chemerin protein levels increased after 4 h of hypoxia at 2.5% O2, with a peak of expression of tumor necrosis factor-alpha (TNF-alpha) at 1 h. Both hypoxia and exogenously added TNF-alpha during normoxia stimulated chemerin expression, whereas an ERK inhibitor (PD98059), ERK small interfering RNA (siRNA), or an anti-TNF-alpha antibody attenuated the chemerin upregulation induced by hypoxia. A gel shift assay indicated that hypoxia induced an increase in DNA-protein binding between the chemerin promoter and transcription factor SP1. A luciferase assay confirmed an increase in transcriptional activity of SP1 on the chemerin promoter during hypoxia. Hypoxia significantly increased the tube formation and migration of HCAECs, whereas PD98059, the anti-TNF-alpha antibody, and chemerin siRNA each attenuated these effects. Conclusion Hypoxia activates chemerin expression in cultured HCAECs. Hypoxia-induced chemerin expression is mediated by TNF-alpha and at least in part by the ERK pathway. Chemerin increases early processes of angiogenesis by HCAECs after hypoxic treatment." @default.
• W2544142007 created "2016-11-04" @default.
• W2544142007 creator A5016615757 @default.
• W2544142007 creator A5021912688 @default.
• W2544142007 creator A5031276640 @default.
• W2544142007 creator A5037967058 @default.
• W2544142007 creator A5053873074 @default.
• W2544142007 creator A5061176033 @default.
• W2544142007 creator A5076960887 @default.
• W2544142007 date "2016-10-28" @default.
• W2544142007 modified "2023-10-17" @default.
• W2544142007 title "Tumor Necrosis Factor-Alpha and the ERK Pathway Drive Chemerin Expression in Response to Hypoxia in Cultured Human Coronary Artery Endothelial Cells" @default.
• W2544142007 cites W1593118353 @default.
• W2544142007 cites W1778265476 @default.
• W2544142007 cites W1966233473 @default.
• W2544142007 cites W1968846807 @default.
• W2544142007 cites W1971068956 @default.
• W2544142007 cites W1981171438 @default.
• W2544142007 cites W1981919404 @default.
• W2544142007 cites W1989700192 @default.
• W2544142007 cites W1993169389 @default.
• W2544142007 cites W2069295502 @default.
• W2544142007 cites W2088667976 @default.
• W2544142007 cites W2092620143 @default.
• W2544142007 cites W2107056568 @default.
• W2544142007 cites W2110385052 @default.
• W2544142007 cites W2119773094 @default.
• W2544142007 cites W2121674856 @default.
• W2544142007 cites W2134195085 @default.
• W2544142007 cites W2138790611 @default.
• W2544142007 cites W2153530045 @default.
• W2544142007 cites W2155377019 @default.
• W2544142007 cites W2168015220 @default.
• W2544142007 cites W2168280979 @default.
• W2544142007 cites W2314259492 @default.
• W2544142007 cites W2396805113 @default.
• W2544142007 doi "https://doi.org/10.1371/journal.pone.0165613" @default.
• W2544142007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5085022" @default.
• W2544142007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27792771" @default.
• W2544142007 hasPublicationYear "2016" @default.
• W2544142007 type Work @default.
• W2544142007 sameAs 2544142007 @default.
• W2544142007 citedByCount "18" @default.
• W2544142007 countsByYear W25441420072017 @default.
• W2544142007 countsByYear W25441420072018 @default.
• W2544142007 countsByYear W25441420072019 @default.
• W2544142007 countsByYear W25441420072020 @default.
• W2544142007 countsByYear W25441420072021 @default.
• W2544142007 countsByYear W25441420072022 @default.
• W2544142007 countsByYear W25441420072023 @default.
• W2544142007 crossrefType "journal-article" @default.
• W2544142007 hasAuthorship W2544142007A5016615757 @default.
• W2544142007 hasAuthorship W2544142007A5021912688 @default.
• W2544142007 hasAuthorship W2544142007A5031276640 @default.
• W2544142007 hasAuthorship W2544142007A5037967058 @default.
• W2544142007 hasAuthorship W2544142007A5053873074 @default.
• W2544142007 hasAuthorship W2544142007A5061176033 @default.
• W2544142007 hasAuthorship W2544142007A5076960887 @default.
• W2544142007 hasBestOaLocation W25441420071 @default.
• W2544142007 hasConcept C104317684 @default.
• W2544142007 hasConcept C126322002 @default.
• W2544142007 hasConcept C127561419 @default.
• W2544142007 hasConcept C134018914 @default.
• W2544142007 hasConcept C153911025 @default.
• W2544142007 hasConcept C178790620 @default.
• W2544142007 hasConcept C17991360 @default.
• W2544142007 hasConcept C185592680 @default.
• W2544142007 hasConcept C194832188 @default.
• W2544142007 hasConcept C199901988 @default.
• W2544142007 hasConcept C22615655 @default.
• W2544142007 hasConcept C2776914184 @default.
• W2544142007 hasConcept C2777391703 @default.
• W2544142007 hasConcept C2779306644 @default.
• W2544142007 hasConcept C2780394083 @default.
• W2544142007 hasConcept C502942594 @default.
• W2544142007 hasConcept C540031477 @default.
• W2544142007 hasConcept C54009773 @default.
• W2544142007 hasConcept C54355233 @default.
• W2544142007 hasConcept C55493867 @default.
• W2544142007 hasConcept C57074206 @default.
• W2544142007 hasConcept C62478195 @default.
• W2544142007 hasConcept C68324877 @default.
• W2544142007 hasConcept C71924100 @default.
• W2544142007 hasConcept C7836513 @default.
• W2544142007 hasConcept C81885089 @default.
• W2544142007 hasConcept C86803240 @default.
• W2544142007 hasConcept C95444343 @default.
• W2544142007 hasConceptScore W2544142007C104317684 @default.
• W2544142007 hasConceptScore W2544142007C126322002 @default.
• W2544142007 hasConceptScore W2544142007C127561419 @default.
• W2544142007 hasConceptScore W2544142007C134018914 @default.
• W2544142007 hasConceptScore W2544142007C153911025 @default.
• W2544142007 hasConceptScore W2544142007C178790620 @default.
• W2544142007 hasConceptScore W2544142007C17991360 @default.
• W2544142007 hasConceptScore W2544142007C185592680 @default.
• W2544142007 hasConceptScore W2544142007C194832188 @default.
• W2544142007 hasConceptScore W2544142007C199901988 @default.
• W2544142007 hasConceptScore W2544142007C22615655 @default.

• next