FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2544333876> ?p ?o ?g. }

• W2544333876 endingPage "42" @default.
• W2544333876 startingPage "35" @default.
• W2544333876 abstract "Two different strategies for the nucleophilic radiosynthesis of [18F]F-DOPA were evaluated regarding their applicability for an automated routine production on an Ecker&Ziegler Modular-Lab Standard module. Initially, we evaluated a promising 5-step synthesis based on a chiral, cinchonidine-derived phase-transfer catalyst (cPTC) being described to give the product in high radiochemical yields (RCY), high specific activities (AS) and high enantiomeric excesses (ee). However, the radiosynthesis of [18F]F-DOPA based on this strategy showed to be highly complex, giving the intermediate products as well as the final product in insufficient yields for automatization. Furthermore, the automatization proved to be problematic due to incomplete radiochemical conversions and the formation of precipitates during the enantioselective reaction step. Furthermore, the required use of HI at 180°C during the last reaction step led to partial decomposition of lines and seals of the module which further counteracts an automatization. Further on, we evaluated a 3-step synthesis using the commercially available, enantiomerically pure precursor AB1336 for automatization. This synthesis approach gave much better results and [18F]F-DOPA could be produced fully automated within 114min in RCYs of 20±1%, ee of >96%, a radiochemical purity (RCP) of >98% and specific activities of up to 2.2GBq/μmol." @default.
• W2544333876 created "2016-11-04" @default.
• W2544333876 creator A5018129572 @default.
• W2544333876 creator A5031336314 @default.
• W2544333876 creator A5044741435 @default.
• W2544333876 creator A5052806645 @default.
• W2544333876 creator A5058921689 @default.
• W2544333876 creator A5081680068 @default.
• W2544333876 date "2017-02-01" @default.
• W2544333876 modified "2023-09-26" @default.
• W2544333876 title "Evaluation of two nucleophilic syntheses routes for the automated synthesis of 6-[18F]fluoro-l-DOPA" @default.
• W2544333876 cites W1639404900 @default.
• W2544333876 cites W1724043070 @default.
• W2544333876 cites W1924178768 @default.
• W2544333876 cites W1967228558 @default.
• W2544333876 cites W1971288173 @default.
• W2544333876 cites W1980586926 @default.
• W2544333876 cites W1981690807 @default.
• W2544333876 cites W1989235961 @default.
• W2544333876 cites W1989893143 @default.
• W2544333876 cites W1992557022 @default.
• W2544333876 cites W1993556224 @default.
• W2544333876 cites W1995435332 @default.
• W2544333876 cites W2011688605 @default.
• W2544333876 cites W2011894816 @default.
• W2544333876 cites W2013376325 @default.
• W2544333876 cites W2014535287 @default.
• W2544333876 cites W2017454453 @default.
• W2544333876 cites W2026940704 @default.
• W2544333876 cites W2029343700 @default.
• W2544333876 cites W2030352060 @default.
• W2544333876 cites W2051140307 @default.
• W2544333876 cites W2051330026 @default.
• W2544333876 cites W2052024706 @default.
• W2544333876 cites W2053395736 @default.
• W2544333876 cites W2053613471 @default.
• W2544333876 cites W2068747155 @default.
• W2544333876 cites W2070275579 @default.
• W2544333876 cites W2072572621 @default.
• W2544333876 cites W2072575857 @default.
• W2544333876 cites W2089148358 @default.
• W2544333876 cites W2093938177 @default.
• W2544333876 cites W2099016712 @default.
• W2544333876 cites W2101801854 @default.
• W2544333876 cites W2107207150 @default.
• W2544333876 cites W2117094798 @default.
• W2544333876 cites W2126000339 @default.
• W2544333876 cites W2133225431 @default.
• W2544333876 cites W2133606607 @default.
• W2544333876 cites W2135129641 @default.
• W2544333876 cites W2146739993 @default.
• W2544333876 cites W2319982645 @default.
• W2544333876 cites W2330696769 @default.
• W2544333876 cites W2408892449 @default.
• W2544333876 cites W2504893583 @default.
• W2544333876 cites W4299966747 @default.
• W2544333876 doi "https://doi.org/10.1016/j.nucmedbio.2016.10.007" @default.
• W2544333876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27886621" @default.
• W2544333876 hasPublicationYear "2017" @default.
• W2544333876 type Work @default.
• W2544333876 sameAs 2544333876 @default.
• W2544333876 citedByCount "20" @default.
• W2544333876 countsByYear W25443338762017 @default.
• W2544333876 countsByYear W25443338762018 @default.
• W2544333876 countsByYear W25443338762019 @default.
• W2544333876 countsByYear W25443338762020 @default.
• W2544333876 countsByYear W25443338762021 @default.
• W2544333876 countsByYear W25443338762022 @default.
• W2544333876 crossrefType "journal-article" @default.
• W2544333876 hasAuthorship W2544333876A5018129572 @default.
• W2544333876 hasAuthorship W2544333876A5031336314 @default.
• W2544333876 hasAuthorship W2544333876A5044741435 @default.
• W2544333876 hasAuthorship W2544333876A5052806645 @default.
• W2544333876 hasAuthorship W2544333876A5058921689 @default.
• W2544333876 hasAuthorship W2544333876A5081680068 @default.
• W2544333876 hasConcept C146686406 @default.
• W2544333876 hasConcept C150903083 @default.
• W2544333876 hasConcept C161790260 @default.
• W2544333876 hasConcept C178790620 @default.
• W2544333876 hasConcept C178907741 @default.
• W2544333876 hasConcept C185592680 @default.
• W2544333876 hasConcept C207001950 @default.
• W2544333876 hasConcept C21951064 @default.
• W2544333876 hasConcept C2776970183 @default.
• W2544333876 hasConcept C486523 @default.
• W2544333876 hasConcept C86803240 @default.
• W2544333876 hasConceptScore W2544333876C146686406 @default.
• W2544333876 hasConceptScore W2544333876C150903083 @default.
• W2544333876 hasConceptScore W2544333876C161790260 @default.
• W2544333876 hasConceptScore W2544333876C178790620 @default.
• W2544333876 hasConceptScore W2544333876C178907741 @default.
• W2544333876 hasConceptScore W2544333876C185592680 @default.
• W2544333876 hasConceptScore W2544333876C207001950 @default.
• W2544333876 hasConceptScore W2544333876C21951064 @default.
• W2544333876 hasConceptScore W2544333876C2776970183 @default.
• W2544333876 hasConceptScore W2544333876C486523 @default.
• W2544333876 hasConceptScore W2544333876C86803240 @default.
• W2544333876 hasLocation W25443338761 @default.

• next