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- W2544334893 abstract "Though DNA sequencing has improved dramatically over the past decade, variant calling, which is the process of reconstructing a patient’s genome from the reads that the sequencers produce, remains a difficult problem, largely due to the genome’s redundant structure. In this thesis, we describe SiRen, our algorithm for characterizing the genome’s structure in a way that makes sense from the perspective of the reads themselves. We use the term similar regions to refer to the areas of redundancy that we have identified. We then confirm that the similar regions are characterized by low variant calling accuracy. We show that the structure of the similar regions provides a platform for repairing alignment errors, thus leading to significantly improved variant calling accuracy." @default.
- W2544334893 created "2016-11-04" @default.
- W2544334893 creator A5028875963 @default.
- W2544334893 date "2015-01-01" @default.
- W2544334893 modified "2023-09-27" @default.
- W2544334893 title "Leveraging Similar Regions to Improve Genome Data Processing" @default.
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- W2544334893 hasPublicationYear "2015" @default.
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