Matches in SemOpenAlex for { <https://semopenalex.org/work/W2544432836> ?p ?o ?g. }
- W2544432836 endingPage "661" @default.
- W2544432836 startingPage "627" @default.
- W2544432836 abstract "Glioblastoma (GBM) is regarded as the most common primary intracranial neoplasm. Despite standard treatment with tumor resection and radiochemotherapy, the outcome remains gloomy. It is evident that a combination of oncogenic gain of function and tumor-suppressive loss of function has been attributed to glioma initiation and progression. The ubiquitin-proteasome system is a well-orchestrated system that controls the fate of most proteins by striking a dynamic balance between ubiquitination and deubiquitination of substrates, having a profound influence on the modulation of oncoproteins, tumor suppressors, and cellular signaling pathways. In recent years, deubiquitinating enzymes (DUBs) have emerged as potential anti-cancer targets due to their targeting several key proteins involved in the regulation of tumorigenesis, apoptosis, senescence, and autophagy. This review attempts to summarize recent studies of GBM-associated DUBs, their roles in various cellular processes, and discuss the relation between DUBs deregulation and gliomagenesis, especially how DUBs regulate glioma stem cells pluripotency, microenvironment, and resistance of radiation and chemotherapy through core stem-cell transcriptional factors. We also review recent achievements and progress in the development of potent and selective reversible inhibitors of DUBs, and attempted to find a potential GBM treatment by DUBs intervention." @default.
- W2544432836 created "2016-11-04" @default.
- W2544432836 creator A5036572434 @default.
- W2544432836 creator A5064248970 @default.
- W2544432836 creator A5075452426 @default.
- W2544432836 date "2016-10-24" @default.
- W2544432836 modified "2023-10-10" @default.
- W2544432836 title "Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges" @default.
- W2544432836 cites W1504025592 @default.
- W2544432836 cites W1505106591 @default.
- W2544432836 cites W1523937142 @default.
- W2544432836 cites W1564987250 @default.
- W2544432836 cites W1625022788 @default.
- W2544432836 cites W177761326 @default.
- W2544432836 cites W1826547551 @default.
- W2544432836 cites W1836761547 @default.
- W2544432836 cites W1840786550 @default.
- W2544432836 cites W1897662255 @default.
- W2544432836 cites W1950155832 @default.
- W2544432836 cites W1962417378 @default.
- W2544432836 cites W1963554305 @default.
- W2544432836 cites W1963937857 @default.
- W2544432836 cites W1965738579 @default.
- W2544432836 cites W1966182875 @default.
- W2544432836 cites W1967115143 @default.
- W2544432836 cites W1967145056 @default.
- W2544432836 cites W1967308267 @default.
- W2544432836 cites W1967402966 @default.
- W2544432836 cites W1967462192 @default.
- W2544432836 cites W1968028576 @default.
- W2544432836 cites W1968526688 @default.
- W2544432836 cites W1969421850 @default.
- W2544432836 cites W1969826673 @default.
- W2544432836 cites W1970431977 @default.
- W2544432836 cites W1970826261 @default.
- W2544432836 cites W1971792138 @default.
- W2544432836 cites W1971893578 @default.
- W2544432836 cites W1972196873 @default.
- W2544432836 cites W1972377269 @default.
- W2544432836 cites W1974868752 @default.
- W2544432836 cites W1975512656 @default.
- W2544432836 cites W1978411300 @default.
- W2544432836 cites W1978493491 @default.
- W2544432836 cites W1979736476 @default.
- W2544432836 cites W1980036978 @default.
- W2544432836 cites W1980106971 @default.
- W2544432836 cites W1980300257 @default.
- W2544432836 cites W1980936182 @default.
- W2544432836 cites W1980991270 @default.
- W2544432836 cites W1981150678 @default.
- W2544432836 cites W1982349128 @default.
- W2544432836 cites W1982936158 @default.
- W2544432836 cites W1985103588 @default.
- W2544432836 cites W1985457111 @default.
- W2544432836 cites W1988225483 @default.
- W2544432836 cites W1988339551 @default.
- W2544432836 cites W1989423211 @default.
- W2544432836 cites W1991249033 @default.
- W2544432836 cites W1991330040 @default.
- W2544432836 cites W1991539695 @default.
- W2544432836 cites W1992938097 @default.
- W2544432836 cites W1993614837 @default.
- W2544432836 cites W1994508000 @default.
- W2544432836 cites W1994568738 @default.
- W2544432836 cites W1994691942 @default.
- W2544432836 cites W1995747121 @default.
- W2544432836 cites W1997146393 @default.
- W2544432836 cites W1998416671 @default.
- W2544432836 cites W1999805583 @default.
- W2544432836 cites W1999816037 @default.
- W2544432836 cites W2000017794 @default.
- W2544432836 cites W2000558685 @default.
- W2544432836 cites W2000577272 @default.
- W2544432836 cites W2002301460 @default.
- W2544432836 cites W2002485539 @default.
- W2544432836 cites W2003428814 @default.
- W2544432836 cites W2003493907 @default.
- W2544432836 cites W2005272618 @default.
- W2544432836 cites W2005548169 @default.
- W2544432836 cites W2005689681 @default.
- W2544432836 cites W2006027217 @default.
- W2544432836 cites W2006548753 @default.
- W2544432836 cites W2006594775 @default.
- W2544432836 cites W2006926781 @default.
- W2544432836 cites W2007072354 @default.
- W2544432836 cites W2007160323 @default.
- W2544432836 cites W2007627662 @default.
- W2544432836 cites W2007706123 @default.
- W2544432836 cites W2007960245 @default.
- W2544432836 cites W2008793606 @default.
- W2544432836 cites W2008922065 @default.
- W2544432836 cites W2010079142 @default.
- W2544432836 cites W2010401946 @default.
- W2544432836 cites W2011236111 @default.
- W2544432836 cites W2012441269 @default.
- W2544432836 cites W2012801703 @default.
- W2544432836 cites W2013412242 @default.
- W2544432836 cites W2013745892 @default.