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- W2544453990 abstract "We herein present an efficient method for the construction of α,α-difluoro-β-hydroxy ketones. The La(OTf)3-catalyzed aldol reaction between difluoroenol O-Boc (Boc = tert-butyloxycarbonyl) esters and carbonyl compounds affords α,α-difluoro-β-hydroxy ketones in good yield. The key reagents of this reaction are the difluoroenol O-Boc esters, which are easily synthesized from trifluoromethyl alcohols in two steps." @default.
- W2544453990 created "2016-11-04" @default.
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- W2544453990 date "2016-12-01" @default.
- W2544453990 modified "2023-10-14" @default.
- W2544453990 title "Synthesis of α,α-difluoro-β-hydroxy ketone via the La(OTf)3-catalyzed aldol reaction of carbonyl compounds with difluoroenol O-Boc esters" @default.
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- W2544453990 doi "https://doi.org/10.1016/j.jfluchem.2016.10.017" @default.
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