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- W2544476743 abstract "Follicular CD4+ T helper (TFH) cells interact with B cells in follicular germinal centers and play a prominent role in promoting effective humoral immune responses to pathogens, providing help for B cell development, and antibody affinity maturation. Recent studies indicate TFH cells are expanded in HIV/SIV chronic infection, or depleted in terminal stages of disease, yet relatively maintained in elite controllers when compared to uninfected controls. A better understanding of the mechanisms behind these immunologic abnormalities may lead to more effective vaccination and therapeutic strategies. Here we review recent findings of TFH cells in HIV/SIV infection, and discuss the correlation of changes and function of TFH cells with host immunity. Dysregulation or depletion of CD4+ TFH cells likely plays a major role in the inability of HIV infected patients to mount effective immune responses." @default.
- W2544476743 created "2016-11-04" @default.
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- W2544476743 date "2016-10-31" @default.
- W2544476743 modified "2023-09-24" @default.
- W2544476743 title "Changes in Follicular CD4+ T Helper Cells as a Marker for Evaluating Disease Progression in the Competition between HIV and Host Immunity" @default.
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- W2544476743 doi "https://doi.org/10.3389/fimmu.2016.00474" @default.
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