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- W2544516601 abstract "Extracellular microRNAs are released from cells both passively and actively. The presence of these microRNAs in the tumour microenvironment (TME) can significantly impact on the plasticity of cancer cells leading to the promotion of metastatic and angiogenic processes. These extracellular microRNAs can act not only on other cancer cells, but also cells present in the TME, such as immune cells, endothelial cells, fibroblasts, and others acting to subvert the host immune system and drive tumour progression. In this review we highlight the current understanding of both the mechanisms by which microRNAs are released from tumour cells and the downstream functional effects that extracellular microRNAs have on recipient cells." @default.
- W2544516601 created "2016-11-04" @default.
- W2544516601 creator A5057934578 @default.
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- W2544516601 date "2017-01-01" @default.
- W2544516601 modified "2023-10-17" @default.
- W2544516601 title "Functional Roles for Exosomal MicroRNAs in the Tumour Microenvironment" @default.
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- W2544516601 doi "https://doi.org/10.1016/j.csbj.2016.10.005" @default.
- W2544516601 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5109280" @default.
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