Matches in SemOpenAlex for { <https://semopenalex.org/work/W2544585346> ?p ?o ?g. }
- W2544585346 endingPage "5280" @default.
- W2544585346 startingPage "5271" @default.
- W2544585346 abstract "Cigarette smoking has been shown to cause pathological alterations in the liver. However, how hepatic metabolism is altered during cigarette smoking‑induced inflammation remains to be fully elucidated. In the present study, a rat model of smoking was established to examine the effects of cigarette smoking on inflammation, autophagy activity, and the expression of nuclear receptor and CYP in the liver. Elevated expression of interleukin 1β and activation of autophagy in the liver were observed upon smoking exposure in rats. Cigarette smoking induced a significant reduction in the mRNA expression levels of cytochromes, including cytochrome P450 (Cyp)1A2, Cyp2D4 and Cyp3A2. Accordingly, a decrease was also observed in glucocorticoid receptor (GR), a regulator of the expression of Cyp. Activation of the GR signal in human hepatic LO2 cells did not affect autophagic genes, however, it led to the upregulation of hCYP1A2, hCYP2C19 and hCYP3A4, and the downregulation of hCYP2C9. The GR antagonist, RU486, eliminated this effect, suggesting the importance of GR in liver metabolism upon cigarette smoking." @default.
- W2544585346 created "2016-11-04" @default.
- W2544585346 creator A5002076433 @default.
- W2544585346 creator A5003118523 @default.
- W2544585346 creator A5004282357 @default.
- W2544585346 creator A5006046188 @default.
- W2544585346 creator A5019452429 @default.
- W2544585346 creator A5021842480 @default.
- W2544585346 creator A5023293666 @default.
- W2544585346 creator A5024648164 @default.
- W2544585346 creator A5027475930 @default.
- W2544585346 creator A5039243214 @default.
- W2544585346 creator A5060531768 @default.
- W2544585346 creator A5067968824 @default.
- W2544585346 creator A5090340144 @default.
- W2544585346 creator A5090438098 @default.
- W2544585346 date "2016-10-27" @default.
- W2544585346 modified "2023-10-18" @default.
- W2544585346 title "Glucocorticoid receptor contributes to the altered expression of hepatic cytochrome P450 upon cigarette smoking" @default.
- W2544585346 cites W1898519536 @default.
- W2544585346 cites W1964524319 @default.
- W2544585346 cites W1966995798 @default.
- W2544585346 cites W1967887971 @default.
- W2544585346 cites W1972996926 @default.
- W2544585346 cites W1977716768 @default.
- W2544585346 cites W1982794896 @default.
- W2544585346 cites W1989038536 @default.
- W2544585346 cites W2001675597 @default.
- W2544585346 cites W2009993652 @default.
- W2544585346 cites W2010427019 @default.
- W2544585346 cites W2020872262 @default.
- W2544585346 cites W2021595206 @default.
- W2544585346 cites W2025614581 @default.
- W2544585346 cites W2029562489 @default.
- W2544585346 cites W2037537142 @default.
- W2544585346 cites W2044634578 @default.
- W2544585346 cites W2056204295 @default.
- W2544585346 cites W2058197170 @default.
- W2544585346 cites W2059378625 @default.
- W2544585346 cites W2059967104 @default.
- W2544585346 cites W2061879307 @default.
- W2544585346 cites W2065279732 @default.
- W2544585346 cites W2071212514 @default.
- W2544585346 cites W2077818019 @default.
- W2544585346 cites W2078881478 @default.
- W2544585346 cites W2083805118 @default.
- W2544585346 cites W2092267763 @default.
- W2544585346 cites W2092740203 @default.
- W2544585346 cites W2099500855 @default.
- W2544585346 cites W2104925243 @default.
- W2544585346 cites W2111754392 @default.
- W2544585346 cites W2111987150 @default.
- W2544585346 cites W2129032743 @default.
- W2544585346 cites W2131923232 @default.
- W2544585346 cites W2133954410 @default.
- W2544585346 cites W2136039969 @default.
- W2544585346 cites W2137082205 @default.
- W2544585346 cites W2147454095 @default.
- W2544585346 cites W2148012276 @default.
- W2544585346 cites W2151282765 @default.
- W2544585346 cites W2155750560 @default.
- W2544585346 cites W2166474305 @default.
- W2544585346 doi "https://doi.org/10.3892/mmr.2016.5898" @default.
- W2544585346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27840998" @default.
- W2544585346 hasPublicationYear "2016" @default.
- W2544585346 type Work @default.
- W2544585346 sameAs 2544585346 @default.
- W2544585346 citedByCount "3" @default.
- W2544585346 countsByYear W25445853462020 @default.
- W2544585346 countsByYear W25445853462021 @default.
- W2544585346 crossrefType "journal-article" @default.
- W2544585346 hasAuthorship W2544585346A5002076433 @default.
- W2544585346 hasAuthorship W2544585346A5003118523 @default.
- W2544585346 hasAuthorship W2544585346A5004282357 @default.
- W2544585346 hasAuthorship W2544585346A5006046188 @default.
- W2544585346 hasAuthorship W2544585346A5019452429 @default.
- W2544585346 hasAuthorship W2544585346A5021842480 @default.
- W2544585346 hasAuthorship W2544585346A5023293666 @default.
- W2544585346 hasAuthorship W2544585346A5024648164 @default.
- W2544585346 hasAuthorship W2544585346A5027475930 @default.
- W2544585346 hasAuthorship W2544585346A5039243214 @default.
- W2544585346 hasAuthorship W2544585346A5060531768 @default.
- W2544585346 hasAuthorship W2544585346A5067968824 @default.
- W2544585346 hasAuthorship W2544585346A5090340144 @default.
- W2544585346 hasAuthorship W2544585346A5090438098 @default.
- W2544585346 hasBestOaLocation W25445853461 @default.
- W2544585346 hasConcept C104317684 @default.
- W2544585346 hasConcept C109650736 @default.
- W2544585346 hasConcept C126322002 @default.
- W2544585346 hasConcept C127561419 @default.
- W2544585346 hasConcept C132040763 @default.
- W2544585346 hasConcept C134018914 @default.
- W2544585346 hasConcept C170493617 @default.
- W2544585346 hasConcept C190283241 @default.
- W2544585346 hasConcept C203522944 @default.
- W2544585346 hasConcept C2776914184 @default.
- W2544585346 hasConcept C2780841215 @default.
- W2544585346 hasConcept C526171541 @default.