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- W2544658166 abstract "To estimate consumptions and spending of anti-MRSA drugs in AP-HP and to assess the relevance of using the defined daily doses (DDDs) of the World Health Organization, a standard dose for an adult of 70 kg, commonly used to evaluate and compare consumptions of drugs, particularly antibiotics. A one day survey was conducted in AP-HP. A set of information (age, weight, drug, real daily dose (RDD), indication, germ) was collected from each patient who received an anti-MRSA drug (daptomycin, linezolid, teicoplanin, vancomycin). First, we calculated and compared spending (€) by valuing RDDs and DDDs with market prices, then we compared average RDDs and DDDs (mg/patient/day) (t-tests). The study included 182 patients (148 adults, 34 children; average weight: 65 kg) from 25/37 hospitals. Total cost for one day is €6,941 with RDDs versus €5,450 with DDDs (+€1,491/day). Differences between average RDDs and DDDs aren’t significant for vancomycin (-166 mg/patient/day; n=121), teicoplanin (+111 mg/patient/day; n=22) and linezolid (-32 mg/patient/day; n=19); but it’s significant for daptomycin (+208 mg/patient/day, p<0,01; n=20). Moreover for vancomycin therapy, difference is significant for children (-1,528 mg/patient/day, p<0,001; n=25); for catheter infections (-814 mg/patient/day, p<0,001; n=50) but not for osteo-joint infections (+290 mg/patient/day; n=35) and febrile neutropenia (+357 mg/patient/day; n=31); among identified germs, difference isn’t significant for MRSA coagulase-negative (-403 mg/patient/day; n=33) but is significant for MRSA (-488 mg/patient/day, p<0,05; n=12). The DDD system is a tool to estimate anti-MRSA drugs consumptions but it doesn’t reflect strictly the medical practices. Globally, DDDs slightly underestimate consumptions in AP-HP. They best correspond with RDDs when doses are independent of body weight and when the drug is used in the therapeutic indication. However, consumptions for children (low body weight) are overestimated. These results should be confirmed in another study including more patients in the subgroups to improve robustness." @default.
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- W2544658166 date "2016-11-01" @default.
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- W2544658166 title "Economic Burden of Anti-Methicillin-Resistant Staphylococcus Aureus (Mrsa) Therapy in Public Hospitals of Paris (Ap-Hp) and Adequacy with the Defined Daily Doses" @default.
- W2544658166 doi "https://doi.org/10.1016/j.jval.2016.09.451" @default.
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