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- W254465863 abstract "Obesity and asthma are both common complex traits responsible for substantial morbidity in the developed world. The consistency of the relationship between obesity and asthma, the temporal and dose-response association, and the correlation of obesity with intermediate phenotypes for asthma suggest that the obesity-asthma link is causal. With few exceptions, the existing epidemiological studies show a consistent positive association of obesity with both incidence and prevalence of asthma in children and adults, with the effect being greater in females than in males. Obesity precedes and predicts the development of asthma, not the other way around, and the effect persists after controlling for diet and physical activity. The dose-response relationship is demonstrated by the finding that the greater the obesity the greater the effect on asthma. Studies are showing improvements in asthma in subjects who lose weight. From these observations, the main research issues at present relate to the actual biological mechanisms by which obesity influences the asthma phenotype. The specific areas requiring further investigation are: direct effect of obesity on mechanical functioning of the lung; changes in the immune or inflammatory responses directly or through genetic mechanism; sex-specific influences relating to hormones; and the influence of maternal diet on fetal programming. At present, we still do not have a good understanding of the precise relationship between obesity and asthma." @default.
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- W254465863 date "2007-01-01" @default.
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- W254465863 title "Obesity and Asthma" @default.
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- W254465863 doi "https://doi.org/10.1007/978-1-59745-370-7_25" @default.
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