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• W2544681213 startingPage "665" @default.
• W2544681213 abstract "Aim: Proteasome inhibitors, such as carfilzomib (CFZ), have shown potential to treat various types of cancers in preclinical models, but clinical applications are limited likely due to formulation and delivery issues. Results & methodology: Tethered polymer nanoassemblies (TNAs) were synthesized by tethering hydrophilic polymers and hydrophobic groups to charged polymer scaffolds, and then end-capping remaining amines on scaffold. Drug entrapment and drug release half-lives increased as charge was removed from scaffold. TNAs with sustained CFZ release maintained drug efficacy after preincubation and increased duration of proteasome inhibition in cancer cells compared with free CFZ. Conclusion: TNAs fine-tuned CFZ release as charge was removed from polymer scaffold, which allowed for sustained proteasome inhibition in cancer cells and potentially enhanced anticancer efficacy." @default.
• W2544681213 created "2016-11-04" @default.
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• W2544681213 date "2016-10-01" @default.
• W2544681213 modified "2023-10-16" @default.
• W2544681213 title "Tethered polymer nanoassemblies for sustained carfilzomib release and prolonged suppression of proteasome activity" @default.
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• W2544681213 doi "https://doi.org/10.4155/tde-2016-0041" @default.
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