Matches in SemOpenAlex for { <https://semopenalex.org/work/W254470748> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W254470748 abstract "The involvement of the NMDA receptor in the neurotoxicity induced by soman, an organophosphorus compound which irreversibly inhibits cholinesterase, was studied in guinea pigs. The drug MK-801 (0.5, 1 or 5 mg/kg, i.p.) was given as a pretreatment before a convulsant dose of soman or as a post treatment (30, 100 or 300 micron g/kg, i.m.) 5 min after the development of soman-induced status epilepticus. Pyridostigmine, atropine and pralidoxime chloride were also given to each subject to counteract the lethality of soman. All subjects that were challenged with soman and given the vehicle for MK-801 (saline) exhibited severe convulsions and electrographic seizure activity. Neuronal necrosis was found in the hippocampus, amygdala, thalamus and the pyriform and cerebral cortices of those subjects surviving for 48 hr. Pretreatment with 0.5 or 1 mg/kg doses of MK-801 did not prevent nor delay the onset of seizure activity but did diminish its intensity and led to its early arrest. At the largest dose (5 mg/kg), MK-801 completely prevented the development of seizure activity and brain damage. Post treatment with MK-801 prevented, arrested or reduced seizure activity, convulsions and neuronal necrosis in a dose-dependent manner. The NMDA receptor may play a more critical role inmore » the spread and maintenance, rather than the initiation of cholinergically-induced seizure activity....Seizure-related brain damage, Organophosphorus compound, Nerve agent, Cholinesterase inhibition, Excitotoxicity, Guinea pig.« less" @default.
- W254470748 created "2016-06-24" @default.
- W254470748 creator A5033183015 @default.
- W254470748 creator A5039637495 @default.
- W254470748 creator A5050991054 @default.
- W254470748 creator A5058371917 @default.
- W254470748 date "1992-12-31" @default.
- W254470748 modified "2023-09-27" @default.
- W254470748 title "Dizocilpine (MK-801) arrests status epilepticus and prevents brain damage induced by Soman. (Reannouncement with new availability information)" @default.
- W254470748 hasPublicationYear "1992" @default.
- W254470748 type Work @default.
- W254470748 sameAs 254470748 @default.
- W254470748 citedByCount "0" @default.
- W254470748 crossrefType "journal-article" @default.
- W254470748 hasAuthorship W254470748A5033183015 @default.
- W254470748 hasAuthorship W254470748A5039637495 @default.
- W254470748 hasAuthorship W254470748A5050991054 @default.
- W254470748 hasAuthorship W254470748A5058371917 @default.
- W254470748 hasConcept C118552586 @default.
- W254470748 hasConcept C126322002 @default.
- W254470748 hasConcept C170493617 @default.
- W254470748 hasConcept C181199279 @default.
- W254470748 hasConcept C185592680 @default.
- W254470748 hasConcept C2775858608 @default.
- W254470748 hasConcept C2777010014 @default.
- W254470748 hasConcept C2777341932 @default.
- W254470748 hasConcept C2777836312 @default.
- W254470748 hasConcept C2778186239 @default.
- W254470748 hasConcept C2778706303 @default.
- W254470748 hasConcept C2778816929 @default.
- W254470748 hasConcept C2778900099 @default.
- W254470748 hasConcept C2780266723 @default.
- W254470748 hasConcept C2781012912 @default.
- W254470748 hasConcept C2781458332 @default.
- W254470748 hasConcept C31896038 @default.
- W254470748 hasConcept C42219234 @default.
- W254470748 hasConcept C55493867 @default.
- W254470748 hasConcept C67018056 @default.
- W254470748 hasConcept C71924100 @default.
- W254470748 hasConcept C98274493 @default.
- W254470748 hasConceptScore W254470748C118552586 @default.
- W254470748 hasConceptScore W254470748C126322002 @default.
- W254470748 hasConceptScore W254470748C170493617 @default.
- W254470748 hasConceptScore W254470748C181199279 @default.
- W254470748 hasConceptScore W254470748C185592680 @default.
- W254470748 hasConceptScore W254470748C2775858608 @default.
- W254470748 hasConceptScore W254470748C2777010014 @default.
- W254470748 hasConceptScore W254470748C2777341932 @default.
- W254470748 hasConceptScore W254470748C2777836312 @default.
- W254470748 hasConceptScore W254470748C2778186239 @default.
- W254470748 hasConceptScore W254470748C2778706303 @default.
- W254470748 hasConceptScore W254470748C2778816929 @default.
- W254470748 hasConceptScore W254470748C2778900099 @default.
- W254470748 hasConceptScore W254470748C2780266723 @default.
- W254470748 hasConceptScore W254470748C2781012912 @default.
- W254470748 hasConceptScore W254470748C2781458332 @default.
- W254470748 hasConceptScore W254470748C31896038 @default.
- W254470748 hasConceptScore W254470748C42219234 @default.
- W254470748 hasConceptScore W254470748C55493867 @default.
- W254470748 hasConceptScore W254470748C67018056 @default.
- W254470748 hasConceptScore W254470748C71924100 @default.
- W254470748 hasConceptScore W254470748C98274493 @default.
- W254470748 hasLocation W2544707481 @default.
- W254470748 hasOpenAccess W254470748 @default.
- W254470748 hasPrimaryLocation W2544707481 @default.
- W254470748 hasRelatedWork W14762853 @default.
- W254470748 hasRelatedWork W1988321110 @default.
- W254470748 hasRelatedWork W2007943181 @default.
- W254470748 hasRelatedWork W2014459302 @default.
- W254470748 hasRelatedWork W2041740977 @default.
- W254470748 hasRelatedWork W2045084950 @default.
- W254470748 hasRelatedWork W2055749276 @default.
- W254470748 hasRelatedWork W2063087871 @default.
- W254470748 hasRelatedWork W2079257658 @default.
- W254470748 hasRelatedWork W2085057138 @default.
- W254470748 hasRelatedWork W2109265817 @default.
- W254470748 hasRelatedWork W2122909350 @default.
- W254470748 hasRelatedWork W2128313731 @default.
- W254470748 hasRelatedWork W2468725095 @default.
- W254470748 hasRelatedWork W2564081044 @default.
- W254470748 hasRelatedWork W2901234143 @default.
- W254470748 hasRelatedWork W3111180268 @default.
- W254470748 hasRelatedWork W3155721323 @default.
- W254470748 hasRelatedWork W329805444 @default.
- W254470748 hasRelatedWork W964394425 @default.
- W254470748 isParatext "false" @default.
- W254470748 isRetracted "false" @default.
- W254470748 magId "254470748" @default.
- W254470748 workType "article" @default.