FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2544869337> ?p ?o ?g. }

• W2544869337 endingPage "E236" @default.
• W2544869337 startingPage "E230" @default.
• W2544869337 abstract "Background: The effect of levosimendan on myocardial performance has not been studied in dialysis-dependent end-stage renal disease patients who have undergone coronary artery bypass grafting (CABG) surgery. Our aim was to investigate the effect of levosimendan on postoperative hemodynamic effects in end-stage renal disease patients undergoing CABG operation.Methods: We performed 58 elective isolated CABG operations in end-stage renal disease patients. The study group received levosimendan at a slow bolus dose of 3 µg/kg, followed by a 24-hour infusion of 0.03-0.05 µg/kg/kg/min. (study group [SG]: n = 25). The remaining patients received a placebo (control group [CG]: n = 33). The mean left ventricular ejection fraction of both groups was similar (44.6 ± 55.4% versus 42.8 ± 53.9%). Hemodynamic data were collected at the end, at 1 hour after CPB, and thereafter at 6, 12, and 24 hours in the ICU. Preoperatively, at the end of the operation, at 1 hour after CPB, and thereafter at 6, 12, and 24 hours in the ICU, blood samples from the peripheral vein were collected for cardiac troponin-I (c-TnI) and lactate levels. Norepinephrine if needed started during the rewarming period in both groups.Results: One patient in SG (4%) and 4 patients (12.1%) in CG died postoperatively (P < .01). Cardiac output and cardiac index values did not change early after weaning from extracorporeal circulation, and they were nearly similar during the next 6 hours in both groups. In SG, cardiac output and cardiac index significantly improved at 6 hours, and were stable at the end of 24 hours (P < .001). Hemodynamic parameters were nearly similar after the operation, and did not change significantly at the end of 24 hours in CG. Hemodynamic improvement caused a significant reduction in systemic and pulmonary artery vascular resistance index in SG (P < .002). Pulmonary capillary wedge pressure decreased significantly in SG (P < .034). Cumulative inotrope dose requirement and intraaortic balloon pump use were significantly lower in SG. In addition, blood lactate and cTnI levels were significanly lower in SG (P < .044).Conclusion: No important adverse effect was detected during levosimendan infusion. Because levosimendan at a dose of 0.03-0.05 μg/kg/min increased myocardial performance significantly in the postoperative period, it can be used safely in end-stage renal disease patients undergoing isolated CABG. The requirement of vasopressors were lower in SG." @default.
• W2544869337 created "2016-11-04" @default.
• W2544869337 creator A5028562181 @default.
• W2544869337 creator A5036926215 @default.
• W2544869337 creator A5037959833 @default.
• W2544869337 creator A5040586520 @default.
• W2544869337 creator A5060643978 @default.
• W2544869337 creator A5063383130 @default.
• W2544869337 creator A5076924291 @default.
• W2544869337 date "2016-10-27" @default.
• W2544869337 modified "2023-10-18" @default.
• W2544869337 title "Levosimendan Use Increases Cardiac Performance after Coronary Artery Bypass Grafting in End-Stage Renal Disease Patients" @default.
• W2544869337 doi "https://doi.org/10.1532/hsf.1426" @default.
• W2544869337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27801303" @default.
• W2544869337 hasPublicationYear "2016" @default.
• W2544869337 type Work @default.
• W2544869337 sameAs 2544869337 @default.
• W2544869337 citedByCount "8" @default.
• W2544869337 countsByYear W25448693372018 @default.
• W2544869337 countsByYear W25448693372019 @default.
• W2544869337 countsByYear W25448693372022 @default.
• W2544869337 crossrefType "journal-article" @default.
• W2544869337 hasAuthorship W2544869337A5028562181 @default.
• W2544869337 hasAuthorship W2544869337A5036926215 @default.
• W2544869337 hasAuthorship W2544869337A5037959833 @default.
• W2544869337 hasAuthorship W2544869337A5040586520 @default.
• W2544869337 hasAuthorship W2544869337A5060643978 @default.
• W2544869337 hasAuthorship W2544869337A5063383130 @default.
• W2544869337 hasAuthorship W2544869337A5076924291 @default.
• W2544869337 hasConcept C126322002 @default.
• W2544869337 hasConcept C139940330 @default.
• W2544869337 hasConcept C164705383 @default.
• W2544869337 hasConcept C178853913 @default.
• W2544869337 hasConcept C2777335384 @default.
• W2544869337 hasConcept C2778063415 @default.
• W2544869337 hasConcept C2778198053 @default.
• W2544869337 hasConcept C2778789114 @default.
• W2544869337 hasConcept C3019040382 @default.
• W2544869337 hasConcept C31861589 @default.
• W2544869337 hasConcept C42219234 @default.
• W2544869337 hasConcept C71924100 @default.
• W2544869337 hasConcept C78085059 @default.
• W2544869337 hasConceptScore W2544869337C126322002 @default.
• W2544869337 hasConceptScore W2544869337C139940330 @default.
• W2544869337 hasConceptScore W2544869337C164705383 @default.
• W2544869337 hasConceptScore W2544869337C178853913 @default.
• W2544869337 hasConceptScore W2544869337C2777335384 @default.
• W2544869337 hasConceptScore W2544869337C2778063415 @default.
• W2544869337 hasConceptScore W2544869337C2778198053 @default.
• W2544869337 hasConceptScore W2544869337C2778789114 @default.
• W2544869337 hasConceptScore W2544869337C3019040382 @default.
• W2544869337 hasConceptScore W2544869337C31861589 @default.
• W2544869337 hasConceptScore W2544869337C42219234 @default.
• W2544869337 hasConceptScore W2544869337C71924100 @default.
• W2544869337 hasConceptScore W2544869337C78085059 @default.
• W2544869337 hasIssue "5" @default.
• W2544869337 hasLocation W25448693371 @default.
• W2544869337 hasLocation W25448693372 @default.
• W2544869337 hasOpenAccess W2544869337 @default.
• W2544869337 hasPrimaryLocation W25448693371 @default.
• W2544869337 hasRelatedWork W2010055778 @default.
• W2544869337 hasRelatedWork W2059447088 @default.
• W2544869337 hasRelatedWork W2062693997 @default.
• W2544869337 hasRelatedWork W2154487865 @default.
• W2544869337 hasRelatedWork W2325219355 @default.
• W2544869337 hasRelatedWork W3154761934 @default.
• W2544869337 hasRelatedWork W3164557477 @default.
• W2544869337 hasRelatedWork W4293757447 @default.
• W2544869337 hasRelatedWork W2182014543 @default.
• W2544869337 hasRelatedWork W2184419740 @default.
• W2544869337 hasVolume "19" @default.
• W2544869337 isParatext "false" @default.
• W2544869337 isRetracted "false" @default.
• W2544869337 magId "2544869337" @default.
• W2544869337 workType "article" @default.