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• W2544937564 abstract "A fundamental motif in canonical nucleic acid structure is the base pair. Mutations that disrupt base pairs are typically destabilizing, but stability can often be restored by a second mutation that replaces the original base pair with an isosteric variant. Such concerted changes are a way to identify helical regions in secondary structures and to identify new functional motifs in sequenced genomes. In principle, such analysis can be extended to non-canonical nucleic acid structures, but this approach has not been utilized because the sequence requirements of such structures are not well understood. Here we investigate the sequence requirements of a G-quadruplex that can both bind GTP and promote peroxidase reactions. Characterization of all 256 variants of the central tetrad in this structure indicates that certain mutations can compensate for canonical G-G-G-G tetrads in the context of both GTP-binding and peroxidase activity. Furthermore, the sequence requirements of these two motifs are significantly different, indicating that tetrad sequence plays a role in determining the biochemical specificity of G-quadruplex activity. Our results provide insight into the sequence requirements of G-quadruplexes, and should facilitate the analysis of such motifs in sequenced genomes." @default.
• W2544937564 created "2016-11-04" @default.
• W2544937564 creator A5031192837 @default.
• W2544937564 creator A5035822235 @default.
• W2544937564 creator A5070808897 @default.
• W2544937564 creator A5090957945 @default.
• W2544937564 date "2016-10-26" @default.
• W2544937564 modified "2023-10-10" @default.
• W2544937564 title "Altered biochemical specificity of G-quadruplexes with mutated tetrads" @default.
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• W2544937564 doi "https://doi.org/10.1093/nar/gkw987" @default.
• W2544937564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5159562" @default.
• W2544937564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27789695" @default.
• W2544937564 hasPublicationYear "2016" @default.
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