Matches in SemOpenAlex for { <https://semopenalex.org/work/W2545025364> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2545025364 abstract "Monolithic matrix tablets of metformin hydrochloride were formulated as extended release tablets by employing ethyl cellulose polymer and the extended release characterization of the formulated tablets was investigated. Extended release matrix tablets containing 500 mg metformin hydrochloride were developed by changing concentration of drug : polymer (EC) in the ratio of 5:1, 5:2, 5:3 and 5:4 by direct compression. Formulations were optimized based on the acceptable tablet properties invitro and invivo drug release. The resulting formulations produced robust tablets with optimum hardness, weight variation, drug content and low friability. The result of invitro and invivo drug release studies indicated that formulation (drug:polymer =5:3), is the most successful of the study and exhibited constant and extended release of metformin hydrochloride 99-100.5% release at the end of 10 h compared with reference standard. Further, the formulation F3 was subjected to exposure at room and accelerated condition to stability studies. A decrease in release of the drug was observed on increasing polymer ratio at certain level. Before tablet compression, the resulting formulation blends were evaluated for angle of repose, bulk density, % porosity, % compressibility index and drug polymer compatibility study of drug and excipients. The t25, t50 and t90 drug release values was calculated from selected formulation F3 on every month of stability studies and comparision of both room and accelerated condition by statistical t-test, there is no difference between storage temperature. The formulation F3 was showed similar invitro and invivo drug release when compared to marketed sustained release tablet (F5M)." @default.
- W2545025364 created "2016-11-04" @default.
- W2545025364 creator A5035748608 @default.
- W2545025364 date "2016-11-01" @default.
- W2545025364 modified "2023-09-23" @default.
- W2545025364 title "Studies on Formulation and Evaluation of Ethyl Cellulose Based Extended Release Metformin Hydrochloride Matrix Tablets" @default.
- W2545025364 cites W1566408227 @default.
- W2545025364 cites W1579286028 @default.
- W2545025364 cites W1587951740 @default.
- W2545025364 cites W1985616613 @default.
- W2545025364 cites W1989429245 @default.
- W2545025364 cites W2005488258 @default.
- W2545025364 cites W2013039941 @default.
- W2545025364 cites W2052425627 @default.
- W2545025364 cites W2071723829 @default.
- W2545025364 cites W2077960795 @default.
- W2545025364 cites W2081637330 @default.
- W2545025364 cites W2145224695 @default.
- W2545025364 cites W2150485492 @default.
- W2545025364 cites W2206070459 @default.
- W2545025364 cites W2297856857 @default.
- W2545025364 cites W2580972929 @default.
- W2545025364 doi "https://doi.org/10.22159/ajpcr.2016.v9i6.14478" @default.
- W2545025364 hasPublicationYear "2016" @default.
- W2545025364 type Work @default.
- W2545025364 sameAs 2545025364 @default.
- W2545025364 citedByCount "0" @default.
- W2545025364 crossrefType "journal-article" @default.
- W2545025364 hasAuthorship W2545025364A5035748608 @default.
- W2545025364 hasBestOaLocation W25450253641 @default.
- W2545025364 hasConcept C106487976 @default.
- W2545025364 hasConcept C134018914 @default.
- W2545025364 hasConcept C151995515 @default.
- W2545025364 hasConcept C159985019 @default.
- W2545025364 hasConcept C185592680 @default.
- W2545025364 hasConcept C191168616 @default.
- W2545025364 hasConcept C192562407 @default.
- W2545025364 hasConcept C2776035855 @default.
- W2545025364 hasConcept C2780035454 @default.
- W2545025364 hasConcept C2780323712 @default.
- W2545025364 hasConcept C2909500757 @default.
- W2545025364 hasConcept C43617362 @default.
- W2545025364 hasConcept C521977710 @default.
- W2545025364 hasConcept C555293320 @default.
- W2545025364 hasConcept C71924100 @default.
- W2545025364 hasConcept C77281830 @default.
- W2545025364 hasConcept C98274493 @default.
- W2545025364 hasConceptScore W2545025364C106487976 @default.
- W2545025364 hasConceptScore W2545025364C134018914 @default.
- W2545025364 hasConceptScore W2545025364C151995515 @default.
- W2545025364 hasConceptScore W2545025364C159985019 @default.
- W2545025364 hasConceptScore W2545025364C185592680 @default.
- W2545025364 hasConceptScore W2545025364C191168616 @default.
- W2545025364 hasConceptScore W2545025364C192562407 @default.
- W2545025364 hasConceptScore W2545025364C2776035855 @default.
- W2545025364 hasConceptScore W2545025364C2780035454 @default.
- W2545025364 hasConceptScore W2545025364C2780323712 @default.
- W2545025364 hasConceptScore W2545025364C2909500757 @default.
- W2545025364 hasConceptScore W2545025364C43617362 @default.
- W2545025364 hasConceptScore W2545025364C521977710 @default.
- W2545025364 hasConceptScore W2545025364C555293320 @default.
- W2545025364 hasConceptScore W2545025364C71924100 @default.
- W2545025364 hasConceptScore W2545025364C77281830 @default.
- W2545025364 hasConceptScore W2545025364C98274493 @default.
- W2545025364 hasLocation W25450253641 @default.
- W2545025364 hasOpenAccess W2545025364 @default.
- W2545025364 hasPrimaryLocation W25450253641 @default.
- W2545025364 hasRelatedWork W1659486684 @default.
- W2545025364 hasRelatedWork W2154228707 @default.
- W2545025364 hasRelatedWork W2181788109 @default.
- W2545025364 hasRelatedWork W2182125090 @default.
- W2545025364 hasRelatedWork W2182882732 @default.
- W2545025364 hasRelatedWork W2184726000 @default.
- W2545025364 hasRelatedWork W2334198342 @default.
- W2545025364 hasRelatedWork W2464926786 @default.
- W2545025364 hasRelatedWork W2601723245 @default.
- W2545025364 hasRelatedWork W2184924439 @default.
- W2545025364 hasRelatedWork W2185737478 @default.
- W2545025364 hasRelatedWork W2186249292 @default.
- W2545025364 hasRelatedWork W2186376726 @default.
- W2545025364 hasRelatedWork W2187077440 @default.
- W2545025364 hasRelatedWork W2187168194 @default.
- W2545025364 hasRelatedWork W2188987071 @default.
- W2545025364 hasRelatedWork W2189474743 @default.
- W2545025364 hasRelatedWork W2461508048 @default.
- W2545025364 hasRelatedWork W2487274296 @default.
- W2545025364 hasRelatedWork W2742002311 @default.
- W2545025364 isParatext "false" @default.
- W2545025364 isRetracted "false" @default.
- W2545025364 magId "2545025364" @default.
- W2545025364 workType "article" @default.