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- W2545260171 abstract "目的探讨白藜芦醇对Aβ1-42刺激HUVECs后凋亡因子Bcl-2／Bax及线粒体跨膜电位和核因子-KB转运的影响。方法5×10^4μmol／LAp1-42刺激HUVECs24h，白藜芦醇干预，干预质量浓度分别为160、80、40和20μg/L，CCK-8法检测细胞活力，荧光显微镜下观察核因子-KB转运情况，罗丹明染色后观察细胞线粒体跨膜电位，Westernblot检测胞质和胞核核因子-KB表达以及Bcl-2／Bax蛋白表达。结果与A6。：组比较，向藜芦醇各组均提高Aβ1-42诱导的HUVECs活力，提高细胞线粒体跨膜电位，抑制NF-κB转运，减少胞NF-κB表达，减少Bax蛋白表达，促进Bcl-2蛋白表达，增加Bcl-2／Bax比值（P〈0．05）。结论白藜芦醇对Aβ1-42致HUVECs损伤有保护效应，可能与抑制NF-κB转运，提高细胞线粒体跨膜电位，增加Bcl-2／Bax比值有关。" @default.
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- W2545260171 date "2016-01-01" @default.
- W2545260171 modified "2023-09-23" @default.
- W2545260171 title "白藜芦醇对Aβ1-42刺激HUVECs后凋亡因子Bcl-2／Bax及线粒体跨膜电位的影响" @default.
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