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- W2545266774 abstract "Growth differentiation factor 15 (GDF-15) is expressed and secreted in response to inflammation, oxidative stress, hypoxia, telomere erosion, and oncogene activation. Cardiovascular (CV) disease is a major driver of GDF-15 production. GDF-15 has favorable preanalytic characteristics and can be measured in serum and plasma by immunoassay.In community-dwelling individuals higher concentrations of GDF-15 are associated with increased risks of developing CV disease, chronic kidney disease, and cancer, independent of traditional CV risk factors, renal function, and other biomarkers (C-reactive protein, B-type natriuretic peptide, cardiac troponin). Low concentrations of GDF-15 are closely associated with longevity. GDF-15 is as an independent marker of all-cause mortality and CV events in patients with coronary artery disease, and may help select patients with non-ST-elevation acute coronary syndrome for early revascularization and more intensive medical therapies. GDF-15 is independently associated with mortality and nonfatal events in atrial fibrillation and heart failure (HF) with preserved or reduced ejection fraction. GDF-15 reflects chronic disease burden and acute perturbations in HF and responds to improvements in hemodynamic status. GDF-15 is independently associated with major bleeding in patients receiving antithrombotic therapies and has been included in a new bleeding risk score, which may become useful for decision support.GDF-15 captures distinct aspects of CV disease development, progression, and prognosis, which are not represented by clinical risk predictors and other biomarkers. The usefulness of GDF-15 to guide management decisions and discover new treatment targets should be further explored." @default.
- W2545266774 created "2016-11-04" @default.
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- W2545266774 creator A5063591215 @default.
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- W2545266774 date "2017-01-01" @default.
- W2545266774 modified "2023-10-17" @default.
- W2545266774 title "Growth Differentiation Factor 15 as a Biomarker in Cardiovascular Disease" @default.
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- W2545266774 doi "https://doi.org/10.1373/clinchem.2016.255174" @default.
- W2545266774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28062617" @default.
- W2545266774 hasPublicationYear "2017" @default.
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