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- W2545366304 abstract "AbstractDegradation study reported on bromhexine hydrochloride is very rare, in this article smart degradation study based on first step neutralization process have been developed for analysis of bromhexine hydrochloride in the presence of its oxidative degradation product. These methods are two chromatographic method (HPLC, TLC densitometric) and one UV spectrophotometric method (first derivative methods). A comparative study between the proposed methods have been developed; TLC densitometric has a major advantage over HPLC method that it can be run using a small quantity of mobile phase, thus lowering the analysis time and the cost with a little higher sensitivity rather than HPLC method. First derivative method requires data processing through derivatization step of the zero spectra of the drug so it can be considered the simplest method in its application. The three methods were validated according to ICH guidelines and statistically compared with a reported spectrophotometric method. The comparison s..." @default.
- W2545366304 created "2016-11-04" @default.
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- W2545366304 date "2016-09-02" @default.
- W2545366304 modified "2023-09-28" @default.
- W2545366304 title "Smart Analytical Study Applied for Quantitative Analysis of Bromhexine Hydrochloride" @default.
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- W2545366304 doi "https://doi.org/10.1080/22297928.2016.1233076" @default.
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