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- W2545380667 abstract "To simulate the impact of a paediatric influenza vaccination programme using a quadrivalent live attenuated influenza vaccine (QLAIV) by applying coverage rates achieved in the UK during the 2014–2015 season to 13 European countries. We used a deterministic, age-structured, dynamic transmission model adapted to the demography, contact patterns and influenza incidence statistics of 13 European countries, with a 10-year time horizon. The reference strategy was the unchanged country-specific coverage rate, using quadrivalent inactivated vaccine (efficacy against infection from 45% in 1-year-old children to 60% in healthy adults). In the evaluated strategy, 56.8% of 5–10-year-old children were additionally vaccinated with QLAIV (efficacy 80%), as was the case in 2014–2015 in the UK’s primary school pilot areas. The evaluated versus reference strategies were compared using odds ratios (OR) for primary care consultations (PCC) in the target (5–10-year-old) and non-target adult (>17-year-old) population as well as number needed to vaccinate (NNV) with QLAIV to avert one PCC, hospitalisation or intensive care unit (ICU) admission. Model outcomes were compared with published real-life data from the UK. Across 13 countries, the resulting range of ORs for PCC was 0.18–0.48 in 5–10-year-old children while the published OR in the UK was 0.06 (95% confidence interval [0.01;0.62]). In adults, the ORs for PCC ranged from 0.60 to 0.91 (UK OR=0.41 [0.19;0.86]). NNV ranged from 7 to 21 per averted PCC (UK NNV=16), 602 to 1699 per averted hospitalisation (UK NNV=317) and 6019 to 16,986 per averted ICU admission (UK NNV=2205). Across a range of European countries, the model provided outcomes similar to published real-life data during a single season in the UK, with beneficial outcomes in the target (children) and non-target (adult) populations, supporting implementation of a programme similar to the UK’s in other European countries. Supported by AstraZeneca." @default.
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- W2545380667 date "2016-11-01" @default.
- W2545380667 modified "2023-09-27" @default.
- W2545380667 title "Translation of the UK Paediatric Influenza Primary School Vaccination Programme to 13 European Countries Using a Dynamic Transmission Model" @default.
- W2545380667 doi "https://doi.org/10.1016/j.jval.2016.09.353" @default.
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