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• W2545646897 abstract "G-quadruplexes (G4s) are DNA secondary structures that are capable of forming and function in vivo The propensity of G4s to exhibit extreme polymorphism and complex dynamics is likely to influence their cellular function, yet a clear microscopic picture of their folding process is lacking. Here we employed single-molecule FRET microscopy to obtain a direct view of the folding and underlying conformational dynamics of G4s formed by the human telomeric sequence in potassium containing solutions. Our experiments allowed detecting several folded states that are populated in the course of G4 folding and determining their folding energetics and timescales. Combining the single-molecule data with molecular dynamics simulations enabled obtaining a structural description of the experimentally observed folded states. Our work thus provides a comprehensive thermodynamic and kinetic description of the folding of G4s that proceeds through a complex multi-route pathway, involving several marginally stable conformational states." @default.
• W2545646897 created "2016-11-04" @default.
• W2545646897 creator A5004658783 @default.
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• W2545646897 date "2016-10-30" @default.
• W2545646897 modified "2023-10-18" @default.
• W2545646897 title "A direct view of the complex multi-pathway folding of telomeric G-quadruplexes" @default.
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• W2545646897 doi "https://doi.org/10.1093/nar/gkw1010" @default.
• W2545646897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5159523" @default.
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• W2545646897 hasPublicationYear "2016" @default.
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