FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2545649410> ?p ?o ?g. }

• W2545649410 endingPage "e2437" @default.
• W2545649410 startingPage "e2437" @default.
• W2545649410 abstract "Abstract Neutrophils have the shortest lifespan among leukocytes and usually die via apoptosis, limiting their deleterious potential. However, this tightly regulated cell death program can be modulated by pathogen-associated molecular patterns (PAMPs), danger-associated molecular pattern (DAMPs), and inflammatory cytokines. We have previously reported that low pH, a hallmark of inflammatory processes and solid tumors, moderately delays neutrophil apoptosis. Here we show that fever-range hyperthermia accelerates the rate of neutrophil apoptosis at neutral pH but markedly increases neutrophil survival induced by low pH. Interestingly, an opposite effect was observed in lymphocytes; hyperthermia plus low pH prevents lymphocyte activation and promotes the death of lymphocytes and lymphoid cell lines. Analysis of the mechanisms through which hyperthermia plus low pH increased neutrophil survival revealed that hyperthermia further decreases cytosolic pH induced by extracellular acidosis. The fact that two Na + /H + exchanger inhibitors, 5-(N-ethyl-N-isopropyl) amiloride (EIPA) and amiloride, reproduced the effects induced by hyperthermia suggested that it prolongs neutrophil survival by inhibiting the Na + /H + antiporter. The neutrophil anti-apoptotic effect induced by PAMPs, DAMPs, and inflammatory cytokines usually leads to the preservation of the major neutrophil effector functions such as phagocytosis and reactive oxygen species (ROS) production. In contrast, our data revealed that the anti-apoptotic effect induced by low pH and hyperthermia induced a functional profile characterized by a low phagocytic activity, an impairment in ROS production and a high ability to suppress T-cell activation and to produce the angiogenic factors VEGF, IL-8, and the matrix metallopeptidase 9 (MMP-9). These results suggest that acting together fever and local acidosis might drive the differentiation of neutrophils into a profile able to promote both cancer progression and tissue repair during the late phase of inflammation, two processes that are strongly dependent on the local production of angiogenic factors by infiltrating immune cells." @default.
• W2545649410 created "2016-11-04" @default.
• W2545649410 creator A5002062431 @default.
• W2545649410 creator A5004158319 @default.
• W2545649410 creator A5005695530 @default.
• W2545649410 creator A5018272765 @default.
• W2545649410 creator A5021702429 @default.
• W2545649410 creator A5023975949 @default.
• W2545649410 creator A5027607751 @default.
• W2545649410 creator A5059868342 @default.
• W2545649410 creator A5069395622 @default.
• W2545649410 creator A5086655484 @default.
• W2545649410 date "2016-10-27" @default.
• W2545649410 modified "2023-10-06" @default.
• W2545649410 title "Fever-range hyperthermia improves the anti-apoptotic effect induced by low pH on human neutrophils promoting a proangiogenic profile" @default.
• W2545649410 cites W1482218233 @default.
• W2545649410 cites W1489532715 @default.
• W2545649410 cites W1534102668 @default.
• W2545649410 cites W1542648807 @default.
• W2545649410 cites W1544568537 @default.
• W2545649410 cites W1567249948 @default.
• W2545649410 cites W1572554526 @default.
• W2545649410 cites W1581404300 @default.
• W2545649410 cites W165023050 @default.
• W2545649410 cites W1831218682 @default.
• W2545649410 cites W1862831991 @default.
• W2545649410 cites W1899229346 @default.
• W2545649410 cites W1903961798 @default.
• W2545649410 cites W1920612549 @default.
• W2545649410 cites W1923009678 @default.
• W2545649410 cites W1940582545 @default.
• W2545649410 cites W1948560807 @default.
• W2545649410 cites W1951140057 @default.
• W2545649410 cites W1973192479 @default.
• W2545649410 cites W1973628719 @default.
• W2545649410 cites W1977051225 @default.
• W2545649410 cites W1982861164 @default.
• W2545649410 cites W1983310780 @default.
• W2545649410 cites W1989776585 @default.
• W2545649410 cites W1990877246 @default.
• W2545649410 cites W1993398535 @default.
• W2545649410 cites W2001037898 @default.
• W2545649410 cites W2003229037 @default.
• W2545649410 cites W2007553857 @default.
• W2545649410 cites W2008317548 @default.
• W2545649410 cites W2010646643 @default.
• W2545649410 cites W2011153931 @default.
• W2545649410 cites W2011592978 @default.
• W2545649410 cites W2014993800 @default.
• W2545649410 cites W2015081253 @default.
• W2545649410 cites W2020986764 @default.
• W2545649410 cites W2032227357 @default.
• W2545649410 cites W2033276755 @default.
• W2545649410 cites W2035566116 @default.
• W2545649410 cites W2036411191 @default.
• W2545649410 cites W2036965973 @default.
• W2545649410 cites W2046926103 @default.
• W2545649410 cites W2052375870 @default.
• W2545649410 cites W2054200174 @default.
• W2545649410 cites W2057391801 @default.
• W2545649410 cites W2078704378 @default.
• W2545649410 cites W2083513831 @default.
• W2545649410 cites W2084538979 @default.
• W2545649410 cites W2123251003 @default.
• W2545649410 cites W2133858793 @default.
• W2545649410 cites W2138694950 @default.
• W2545649410 cites W2143455089 @default.
• W2545649410 cites W2147550222 @default.
• W2545649410 cites W2157712155 @default.
• W2545649410 cites W2164940139 @default.
• W2545649410 cites W2167795547 @default.
• W2545649410 cites W2168388460 @default.
• W2545649410 cites W2168887400 @default.
• W2545649410 cites W2330235583 @default.
• W2545649410 cites W2580449060 @default.
• W2545649410 doi "https://doi.org/10.1038/cddis.2016.337" @default.
• W2545649410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5133997" @default.
• W2545649410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27787523" @default.
• W2545649410 hasPublicationYear "2016" @default.
• W2545649410 type Work @default.
• W2545649410 sameAs 2545649410 @default.
• W2545649410 citedByCount "24" @default.
• W2545649410 countsByYear W25456494102018 @default.
• W2545649410 countsByYear W25456494102019 @default.
• W2545649410 countsByYear W25456494102020 @default.
• W2545649410 countsByYear W25456494102021 @default.
• W2545649410 countsByYear W25456494102022 @default.
• W2545649410 countsByYear W25456494102023 @default.
• W2545649410 crossrefType "journal-article" @default.
• W2545649410 hasAuthorship W2545649410A5002062431 @default.
• W2545649410 hasAuthorship W2545649410A5004158319 @default.
• W2545649410 hasAuthorship W2545649410A5005695530 @default.
• W2545649410 hasAuthorship W2545649410A5018272765 @default.
• W2545649410 hasAuthorship W2545649410A5021702429 @default.
• W2545649410 hasAuthorship W2545649410A5023975949 @default.
• W2545649410 hasAuthorship W2545649410A5027607751 @default.
• W2545649410 hasAuthorship W2545649410A5059868342 @default.
• W2545649410 hasAuthorship W2545649410A5069395622 @default.

• next