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- W2545668519 abstract "Transient receptor potential A1 (TRPA1) is a nonselective cation channel implicated in thermosensation and inflammatory pain. In this study, we show that TRPA1 (activated by allyl isothiocyanate, acrolein, and 4-hydroxynonenal) elevates the intracellular Ca2+ concentration ([Ca2+]i) in dorsal root ganglion (DRG) neurons in the presence and absence of extracellular Ca2+. Pharmacological and immunocytochemical analyses revealed the presence of TRPA1 channels both on the plasma membrane and in endolysosomes. Confocal line-scan imaging demonstrated Ca2+ signals elicited from individual endolysosomes (“lysosome Ca2+ sparks”) by TRPA1 activation. In physiological solutions, the TRPA1-mediated endolysosomal Ca2+ release contributed to ∼40% of the overall [Ca2+]i rise and directly triggered vesicle exocytosis and calcitonin gene-related peptide release, which greatly enhanced the excitability of DRG neurons. Thus, in addition to working via Ca2+ influx, TRPA1 channels trigger vesicle release in sensory neurons by releasing Ca2+ from lysosome-like organelles." @default.
- W2545668519 created "2016-11-04" @default.
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- W2545668519 date "2016-10-31" @default.
- W2545668519 modified "2023-10-16" @default.
- W2545668519 title "Intracellular TRPA1 mediates Ca2+ release from lysosomes in dorsal root ganglion neurons" @default.
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- W2545668519 doi "https://doi.org/10.1083/jcb.201603081" @default.
- W2545668519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5100290" @default.
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- W2545668519 hasPublicationYear "2016" @default.
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