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- W2545908345 abstract "Control of intestinal epithelial stemness is crucial for tissue homeostasis. Disturbances in epithelial function are implicated in inflammatory and neoplastic diseases of the gastrointestinal tract. Here we report that mitochondrial function plays a critical role in maintaining intestinal stemness and homeostasis. Using intestinal epithelial cell (IEC)-specific mouse models, we show that loss of HSP60, a mitochondrial chaperone, activates the mitochondrial unfolded protein response (MT-UPR) and results in mitochondrial dysfunction. HSP60-deficient crypts display loss of stemness and cell proliferation, accompanied by epithelial release of WNT10A and RSPO1. Sporadic failure of Cre-mediated Hsp60 deletion gives rise to hyperproliferative crypt foci originating from OLFM4+ stem cells. These effects are independent of the MT-UPR-associated transcription factor CHOP. In conclusion, compensatory hyperproliferation of HSP60+ escaper stem cells suggests paracrine release of WNT-related factors from HSP60-deficient, functionally impaired IEC to be pivotal in the control of the proliferative capacity of the stem cell niche." @default.
- W2545908345 created "2016-11-04" @default.
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- W2545908345 date "2016-10-27" @default.
- W2545908345 modified "2023-10-18" @default.
- W2545908345 title "Mitochondrial function controls intestinal epithelial stemness and proliferation" @default.
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- W2545908345 cites W1981996404 @default.
- W2545908345 cites W1983571964 @default.
- W2545908345 cites W1984368973 @default.
- W2545908345 cites W1985264218 @default.
- W2545908345 cites W1985766240 @default.
- W2545908345 cites W1990606472 @default.
- W2545908345 cites W1991592461 @default.
- W2545908345 cites W1994367371 @default.
- W2545908345 cites W1994800660 @default.
- W2545908345 cites W1997944110 @default.
- W2545908345 cites W2006043716 @default.
- W2545908345 cites W2011910303 @default.
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- W2545908345 cites W2026788098 @default.
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- W2545908345 cites W2042365690 @default.
- W2545908345 cites W2043880988 @default.
- W2545908345 cites W2062775685 @default.
- W2545908345 cites W2069924169 @default.
- W2545908345 cites W2073423435 @default.
- W2545908345 cites W2074471441 @default.
- W2545908345 cites W2081422975 @default.
- W2545908345 cites W2081762851 @default.
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- W2545908345 cites W2092824183 @default.
- W2545908345 cites W2095048801 @default.
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- W2545908345 cites W2096461105 @default.
- W2545908345 cites W2099662390 @default.
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- W2545908345 cites W2104081204 @default.
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- W2545908345 cites W2133728642 @default.
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- W2545908345 cites W2160473148 @default.
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- W2545908345 cites W2168623286 @default.
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- W2545908345 doi "https://doi.org/10.1038/ncomms13171" @default.
- W2545908345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5080445" @default.
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- W2545908345 hasPublicationYear "2016" @default.
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