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- W2546032912 endingPage "736" @default.
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- W2546032912 abstract "The WHO recommends integration of universal mass vaccination (UMV) against hepatitis A virus (HAV) in national immunization schedules for children aged ≥1 year, if justified on the basis of acute HAV incidence, declining endemicity from high to intermediate and cost-effectiveness. This recommendation has been implemented in several countries. Our aim was to assess the impact of UMV using monovalent inactivated hepatitis A vaccines on incidence and persistence of anti-HAV (IgG) antibodies in pediatric populations. We conducted a systematic review of literature published between 2000 and 2015 in PubMed, Cochrane Library, LILACS, IBECS identifying a total of 27 studies (Argentina, Belgium, China, Greece, Israel, Panama, the United States and Uruguay). All except one study showed a marked decline in the incidence of hepatitis A post introduction of UMV. The incidence in non-vaccinated age groups decreased as well, suggesting herd immunity but also rising susceptibility. Long-term anti-HAV antibody persistence was documented up to 17 y after a 2-dose primary vaccination. In conclusion, introduction of UMV in countries with intermediate endemicity for HAV infection led to a considerable decrease in the incidence of hepatitis A in vaccinated and in non-vaccinated age groups alike." @default.
- W2546032912 created "2016-11-04" @default.
- W2546032912 creator A5001013986 @default.
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- W2546032912 date "2016-10-27" @default.
- W2546032912 modified "2023-10-18" @default.
- W2546032912 title "Impact of universal mass vaccination with monovalent inactivated hepatitis A vaccines – A systematic review" @default.
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- W2546032912 doi "https://doi.org/10.1080/21645515.2016.1242539" @default.
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