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- W2546246019 abstract "This study aims to evaluate the clinical effectiveness of carbapenems compare to other alternative antibiotics in treating bacteremia caused by ESBL. Data from patients with ESBL positive batereamia was retrospectively collected from four hospitals from 1 January 2010 to 31 December 2014. The primary outcome was the mortality within 30 days. Since the clinical characteristics of patients can affect the selection of antibiotics, basic analysis including all subjects who met inclusion and exclusion criteria as well as an analysis using “stabilized Inverse Probability of Treatment Weighting (stabilized IPTW)” that adjusted patient clinical characteristics were conducted. We identified 554 patients who met the eligibility criteria. There was no statistically significant difference in thirty day survival rate between the groups both prior and post to propensity score weighting in empirical treatment. Multivariate analysis of thirty day survival rate conducted after the adjustment of confounding variables affecting mortality rate such as age, infection route, transfer to ICU within 48 hours, infection sites, APACHE II, liver diseases, lung diseases, renal disease and diabetes also revealed that there was no significant difference (HR=1.01, 95%CI 0.27-3.76). After propensity score weighting, the statistical difference remained insignificant (weighted HR=0.76, 95%CI 0.23-2.58). There was no statistically significant difference in thirty day survival rate between the groups when carbapenems and BL/BLIs were used as empirical treatment (weighted HR=0.99, 95%CI 0.29-3.30). The results from this study show that there was no difference in mortality when carbapenems were compared with BL/BLIs alone or with all alternative antibiotics as empirical therapy. Although the role of carbapenems as definitive treatment should be evaluated, considering an increasing carbapenem resistance, alternative antibiotics, such as BL/BLIs, can be used as alternatives for the empirical treatment of patients with ESBL-positive enterobacteriaceae bacteraemia." @default.
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- W2546246019 date "2016-11-01" @default.
- W2546246019 modified "2023-09-30" @default.
- W2546246019 title "Comparative Effectiveness of Carbapenems Versus Alternative Antibiotics for the Treatment of Bacteraemia Due to Enterobacteriaceae Producing Extended - Spectrum β-Lactamase in Empirical Therapy: Multicenter Cohort Study" @default.
- W2546246019 doi "https://doi.org/10.1016/j.jval.2016.09.352" @default.
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