Matches in SemOpenAlex for { <https://semopenalex.org/work/W2546424836> ?p ?o ?g. }
- W2546424836 endingPage "373" @default.
- W2546424836 startingPage "365" @default.
- W2546424836 abstract "Pramipexole (PPX), a dopamine D2/3 receptor preferring agonist, is currently in use for the treatment of Parkinson's disease symptoms and restless legs syndrome. Recently, anti-inflammatory properties of PPX have been shown in an autoimmune model of multiple sclerosis, and case reports indicate PPX ameliorates depressive symptoms. Since peripheral inflammation is known to induce depression-like behavior in rodents, we assessed the potential antidepressant effect of PPX in an inflammatory model of depression induced by LPS. Repeated (daily for 7days, 1mg/kg, i.p.), but not acute (1h before LPS) treatment with PPX abolished the depression-like behavior induced by LPS (0.1mg/kg, i.p.) in the forced swim test, and the anhedonic behavior in the splash test. Interestingly, PPX per se decreased interleukin 1β levels and reversed LPS-induced increase in its content in mice hippocampus⋅ Repeated PPX treatment also prevented the increase in hippocampal levels of the 3-nitrotyrosine protein adducts induced by LPS. Haloperidol (0.2mg/kg, i.p.) and sulpiride (50mg/kg, i.p.) were unable to prevent the antidepressant-like effect of PPX in LPS-treated mice. Altogether, these results suggest that the observed antidepressant-like effect of PPX in LPS-treated mice may be dependent on its anti-inflammatory properties and may not be related to dopamine D2 receptor activation." @default.
- W2546424836 created "2016-11-11" @default.
- W2546424836 creator A5000135625 @default.
- W2546424836 creator A5031221345 @default.
- W2546424836 creator A5033223118 @default.
- W2546424836 creator A5033712903 @default.
- W2546424836 creator A5047721445 @default.
- W2546424836 creator A5053335750 @default.
- W2546424836 creator A5059926305 @default.
- W2546424836 creator A5074496340 @default.
- W2546424836 creator A5079922285 @default.
- W2546424836 date "2017-03-01" @default.
- W2546424836 modified "2023-10-10" @default.
- W2546424836 title "Antidepressant-like effect of pramipexole in an inflammatory model of depression" @default.
- W2546424836 cites W1843400861 @default.
- W2546424836 cites W1861269408 @default.
- W2546424836 cites W1963937961 @default.
- W2546424836 cites W1976609253 @default.
- W2546424836 cites W1979705133 @default.
- W2546424836 cites W1980555794 @default.
- W2546424836 cites W1982754908 @default.
- W2546424836 cites W1988940166 @default.
- W2546424836 cites W1993573489 @default.
- W2546424836 cites W1997503261 @default.
- W2546424836 cites W2008202586 @default.
- W2546424836 cites W2016292245 @default.
- W2546424836 cites W2020694798 @default.
- W2546424836 cites W2024332026 @default.
- W2546424836 cites W2025016146 @default.
- W2546424836 cites W2033215199 @default.
- W2546424836 cites W2035417313 @default.
- W2546424836 cites W2043189848 @default.
- W2546424836 cites W2044057452 @default.
- W2546424836 cites W2047670437 @default.
- W2546424836 cites W2047936696 @default.
- W2546424836 cites W2048938277 @default.
- W2546424836 cites W2056037521 @default.
- W2546424836 cites W2060351300 @default.
- W2546424836 cites W2065520804 @default.
- W2546424836 cites W2068698561 @default.
- W2546424836 cites W2071962757 @default.
- W2546424836 cites W2073609618 @default.
- W2546424836 cites W2081873854 @default.
- W2546424836 cites W2087396716 @default.
- W2546424836 cites W2090055848 @default.
- W2546424836 cites W2099516158 @default.
- W2546424836 cites W2100222481 @default.
- W2546424836 cites W2103071544 @default.
- W2546424836 cites W2116232103 @default.
- W2546424836 cites W2117124193 @default.
- W2546424836 cites W2117300196 @default.
- W2546424836 cites W2122225404 @default.
- W2546424836 cites W2125984173 @default.
- W2546424836 cites W2126795224 @default.
- W2546424836 cites W2133362506 @default.
- W2546424836 cites W2136371177 @default.
- W2546424836 cites W2152958471 @default.
- W2546424836 cites W2158978919 @default.
- W2546424836 cites W2162861984 @default.
- W2546424836 cites W2172826366 @default.
- W2546424836 cites W2196826730 @default.
- W2546424836 cites W2201607793 @default.
- W2546424836 cites W2230320678 @default.
- W2546424836 cites W2237598232 @default.
- W2546424836 cites W2260677129 @default.
- W2546424836 cites W2268366841 @default.
- W2546424836 cites W2296450808 @default.
- W2546424836 cites W2314335495 @default.
- W2546424836 cites W2338409004 @default.
- W2546424836 cites W2339334048 @default.
- W2546424836 cites W2417501132 @default.
- W2546424836 cites W2469896077 @default.
- W2546424836 cites W2506909361 @default.
- W2546424836 cites W4240381454 @default.
- W2546424836 cites W813135828 @default.
- W2546424836 doi "https://doi.org/10.1016/j.bbr.2016.11.007" @default.
- W2546424836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27825895" @default.
- W2546424836 hasPublicationYear "2017" @default.
- W2546424836 type Work @default.
- W2546424836 sameAs 2546424836 @default.
- W2546424836 citedByCount "33" @default.
- W2546424836 countsByYear W25464248362018 @default.
- W2546424836 countsByYear W25464248362019 @default.
- W2546424836 countsByYear W25464248362020 @default.
- W2546424836 countsByYear W25464248362021 @default.
- W2546424836 countsByYear W25464248362022 @default.
- W2546424836 countsByYear W25464248362023 @default.
- W2546424836 crossrefType "journal-article" @default.
- W2546424836 hasAuthorship W2546424836A5000135625 @default.
- W2546424836 hasAuthorship W2546424836A5031221345 @default.
- W2546424836 hasAuthorship W2546424836A5033223118 @default.
- W2546424836 hasAuthorship W2546424836A5033712903 @default.
- W2546424836 hasAuthorship W2546424836A5047721445 @default.
- W2546424836 hasAuthorship W2546424836A5053335750 @default.
- W2546424836 hasAuthorship W2546424836A5059926305 @default.
- W2546424836 hasAuthorship W2546424836A5074496340 @default.
- W2546424836 hasAuthorship W2546424836A5079922285 @default.
- W2546424836 hasConcept C118552586 @default.