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- W2546592744 abstract "Mice have been commonly used for different purposes in a variety of preclinical studies, mainly because of the availability of a wide range of disease models as well as genetically altered animals. It is, however, necessary to develop elemental technology that is optimized for mouse-specific measurements to achieve a successful outcome from magnetic resonance (MR) studies using hyperpolarized (HP) noble gases (e.g., 129 Xe and 3 He). In this chapter, we provide a brief overview of the recent progress made by our group in the development of HP 129 Xe MR measurements at 9.4 Tesla. Our research focuses on HP 129 Xe MR spectroscopy and imaging in mice that spontaneously inhale the HP 129 Xe continuously delivered from a hyperpolarizer. This simple and noninvasive protocol allows us to perform HP 129 Xe MR studies in mice under natural physiological conditions. Some successful examples of this protocol are summarized in assessing physiological conditions related to pulmonary functions." @default.
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- W2546592744 date "2017-01-01" @default.
- W2546592744 modified "2023-10-14" @default.
- W2546592744 title "Development and Application of Mouse Imaging Using Hyperpolarized Xenon" @default.
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- W2546592744 doi "https://doi.org/10.1016/b978-0-12-803675-4.00008-7" @default.
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