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- W2546661444 abstract "Optogenetic methods have been highly effective for suppressing neural activity and modulating behavior in rodents, but effects have been much smaller in primates, which have much larger brains. Here, we present a suite of technologies to use optogenetics effectively in primates and apply these tools to a classic question in oculomotor control. First, we measured light absorption and heat propagation in vivo, optimized the conditions for using the red-light-shifted halorhodopsin Jaws in primates, and developed a large-volume illuminator to maximize light delivery with minimal heating and tissue displacement. Together, these advances allowed for nearly universal neuronal inactivation across more than 10 mm3 of the cortex. Using these tools, we demonstrated large behavioral changes (i.e., up to several fold increases in error rate) with relatively low light power densities (≤100 mW/mm2) in the frontal eye field (FEF). Pharmacological inactivation studies have shown that the FEF is critical for executing saccades to remembered locations. FEF neurons increase their firing rate during the three epochs of the memory-guided saccade task: visual stimulus presentation, the delay interval, and motor preparation. It is unclear from earlier work, however, whether FEF activity during each epoch is necessary for memory-guided saccade execution. By harnessing the temporal specificity of optogenetics, we found that FEF contributes to memory-guided eye movements during every epoch of the memory-guided saccade task (the visual, delay, and motor periods)." @default.
- W2546661444 created "2016-11-11" @default.
- W2546661444 creator A5011943890 @default.
- W2546661444 creator A5029086323 @default.
- W2546661444 creator A5081911616 @default.
- W2546661444 creator A5086953418 @default.
- W2546661444 date "2016-11-02" @default.
- W2546661444 modified "2023-10-15" @default.
- W2546661444 title "FEF inactivation with improved optogenetic methods" @default.
- W2546661444 cites W106863210 @default.
- W2546661444 cites W144830725 @default.
- W2546661444 cites W1543674079 @default.
- W2546661444 cites W1545365849 @default.
- W2546661444 cites W1555544573 @default.
- W2546661444 cites W1831205814 @default.
- W2546661444 cites W1912996233 @default.
- W2546661444 cites W1957364793 @default.
- W2546661444 cites W1963937305 @default.
- W2546661444 cites W1972966292 @default.
- W2546661444 cites W1973468287 @default.
- W2546661444 cites W1973614121 @default.
- W2546661444 cites W1979058252 @default.
- W2546661444 cites W1984390450 @default.
- W2546661444 cites W1985854422 @default.
- W2546661444 cites W1987022782 @default.
- W2546661444 cites W1987173769 @default.
- W2546661444 cites W1997457635 @default.
- W2546661444 cites W1997480207 @default.
- W2546661444 cites W1998604513 @default.
- W2546661444 cites W2005926822 @default.
- W2546661444 cites W2009534332 @default.
- W2546661444 cites W2013492930 @default.
- W2546661444 cites W2013529001 @default.
- W2546661444 cites W2013927030 @default.
- W2546661444 cites W2016096979 @default.
- W2546661444 cites W2021308189 @default.
- W2546661444 cites W2021750959 @default.
- W2546661444 cites W2029532682 @default.
- W2546661444 cites W2031545502 @default.
- W2546661444 cites W2033922262 @default.
- W2546661444 cites W2036420764 @default.
- W2546661444 cites W2043858094 @default.
- W2546661444 cites W2047271528 @default.
- W2546661444 cites W2047616560 @default.
- W2546661444 cites W2048767020 @default.
- W2546661444 cites W2049730553 @default.
- W2546661444 cites W2050054249 @default.
- W2546661444 cites W2050681642 @default.
- W2546661444 cites W2050932531 @default.
- W2546661444 cites W2054041034 @default.
- W2546661444 cites W2058082904 @default.
- W2546661444 cites W2062768925 @default.
- W2546661444 cites W2063342408 @default.
- W2546661444 cites W2063546265 @default.
- W2546661444 cites W2063996475 @default.
- W2546661444 cites W2064139020 @default.
- W2546661444 cites W2065128164 @default.
- W2546661444 cites W2065141834 @default.
- W2546661444 cites W2068702958 @default.
- W2546661444 cites W2069041575 @default.
- W2546661444 cites W2077579927 @default.
- W2546661444 cites W2079499313 @default.
- W2546661444 cites W2084374696 @default.
- W2546661444 cites W2084506653 @default.
- W2546661444 cites W2086379021 @default.
- W2546661444 cites W2089758692 @default.
- W2546661444 cites W2092890445 @default.
- W2546661444 cites W2094955398 @default.
- W2546661444 cites W2099656082 @default.
- W2546661444 cites W2104698815 @default.
- W2546661444 cites W2108928489 @default.
- W2546661444 cites W2109230507 @default.
- W2546661444 cites W2116162249 @default.
- W2546661444 cites W2116799948 @default.
- W2546661444 cites W2120229762 @default.
- W2546661444 cites W2122682100 @default.
- W2546661444 cites W2124266675 @default.
- W2546661444 cites W2126430831 @default.
- W2546661444 cites W2128929894 @default.
- W2546661444 cites W2129220462 @default.
- W2546661444 cites W2130909150 @default.
- W2546661444 cites W2131851399 @default.
- W2546661444 cites W2139272195 @default.
- W2546661444 cites W2143732412 @default.
- W2546661444 cites W2146584976 @default.
- W2546661444 cites W2146917989 @default.
- W2546661444 cites W2158601670 @default.
- W2546661444 cites W2160961804 @default.
- W2546661444 cites W2161655132 @default.
- W2546661444 cites W2161780951 @default.
- W2546661444 cites W2166377999 @default.
- W2546661444 cites W2166512953 @default.
- W2546661444 cites W2169118010 @default.
- W2546661444 cites W2170876384 @default.
- W2546661444 cites W2171509705 @default.
- W2546661444 cites W2207914931 @default.
- W2546661444 cites W2271615357 @default.
- W2546661444 cites W2281172388 @default.
- W2546661444 cites W2410888546 @default.
- W2546661444 cites W4231734219 @default.