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- W254669240 abstract "[Objective] To analyze the anti-HIV activities and cytotoxicity of silver nanoparticles.[Methods] C8166 cells were infected with HIV-1 or HIV-2 strains.The cytopathic effect(CPE) was measured by counting the number of syncytium.The p24 in the supernatant was examined by ELISA.To examine the virucide activity,HIV-1IIIB was incubated with silver nanoparticles for 1 h and virus was added.Syncytia were scored after 72h.Cytotoxicity to C8166 cells was assessed by MTT method.To test toxicology in vivo,the mice were given nasal dropping of silver nanoparticles.Mice weight and histological section of liver,lung and renal tissues were examined.[Results] Silver nanoparticles suppressed syncytium formation in HIV1 IIIB or HIV-2CBL-20 infected C8166 cell line with EC50 value of 26.56 μg /ml and 35.47 μg /ml,respectively.It also reduced p24 production in HIV-1IIIB acute infected C8166 with EC50 value of 9.80 μg /ml.Further,silver nanoparticles showed virucide activity with EC50 value of 12.08 μg /ml.Nasal dropping of silver nanoparticles showed effect neither on mice's weight nor on liver,lung and renal tissues.[Conclusion] Silver nanoparticles can inhibit HIV-1 and HIV-2 replication in vitro by its virucide activity.No acute toxicity is found on the mice treated by nasal dropping of silver nanoparticles." @default.
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- W254669240 date "2009-01-01" @default.
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- W254669240 title "Study on anti-HIV activity of silver nanoparticles in vitro." @default.
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