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• W2546702957 abstract "Objective: To clarify whether carotid atherosclerosis and its risk factors contribute to function. Background: Both of two major types of dementia: vascular dementia and Alzheimers disease shares pathogenesis related to atherosclerosis. Carotid intima-media thickness (IMT) is widely used for assessing atherosclerosis. Some study has reported association of increased carotid IMT and function, but it remains controversial. Methods: Two hundred and six individuals who visited our center for health screening were evaluated with physical examination, blood test, carotid ultrasonography, brain MRI scanning, and function tests. Cognitive function assessment included Mini-Mental State Examination (MMSE), Clock Drawing Test (CDT), and logical memory of Wechsler Memory Scale (WMS-R). Thirty individuals with cerebrovascular lesions by MRI scanning were excluded. To detect early decline, we defined cognitive impairment (CI) when an individual satisfied at least one of three criteria; 1)MMSE score under 24, 2)CDT score under 4 coexistent with forgetfulness, and 3)WMS-R delayed recall score under normal range for each educational length (over 16 years: 蠅9, 10-15 years: 蠅5, 0-9 years: 蠅3), according to Alzheimer9s Disease Neuroimaging Initiative (ADNI) late MCI criteria. Results: Among 176 individuals, 27 were classified as CI group. Maximum IMT was significantly increased in CI group than in non-CI group (meanSD: 2.01.0 vs 1.70.7, p =0.018) by student t -test. Other atherosclerotic risk factors; blood pressure, LDL-cholesterol, and HbA1c were not significantly different between two groups. In multivariate analysis, no single risk factor of atherosclerosis contributed to each function assessment. However, carotid IMT was associated with impaired immediate recall score of WMS-R independently to deep white matter hyperintensity on MRI scan. Conclusions: Subclinical carotid atherosclerosis assessed as thickened IMT can be a marker of early stage of impairment especially immediate memory recall presumably by cerebral microvascular dysfunction in frontal lobe. Disclosure: Dr. Matsumoto has nothing to disclose. Dr. Suzuki has nothing to disclose. Dr. Mizuno has received research support from Merck Sharp & Dohme Limited. Dr. Ohike has nothing to disclose. Dr. Ozeki has nothing to disclose. Dr. Ono has nothing to disclose. Dr. Takanashi has received research support from MSD. Dr. Sawaki has nothing to disclose. Dr. Suzuki has received research support from Shionogi. Dr. Yamazaki has nothing to disclose. Dr. Tsuji has nothing to disclose. Dr. Iwata has received personal compensation for activities with Eisai, Daiichi Sankyo, Chugai, Janssen, Takeda, and Ono Pharmaceuticals." @default.
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• W2546702957 date "2016-04-05" @default.
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• W2546702957 title "Subclinical carotid atherosclerosis associates with impairment in immediate memory (P1.101)" @default.
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