Matches in SemOpenAlex for { <https://semopenalex.org/work/W2546780780> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2546780780 abstract "AbstractType 1 diabetes is considered to be a T cell-mediated autoimmune disease characterized by destruction of the pancreatic beta cells. Its prediction is currently based on diabetes-associated autoantibodies, giving a cumulative risk of 84% during 15 years of follow-up since seroconversion. Prediction of the timing of clinical onset has remained challenging, however. This thesis examines glucose metabolism in autoantibody-positive children with a high risk of developing type 1 diabetes. Out of a total of 14,876 children with an increased genetic risk followed up from birth in the Finnish DIPP study, 567 developed ≥2 autoantibodies during the follow-up and 255 of these (45%) were diagnosed with type 1 diabetes until the end of December 2011. The glucose parameters measured were HbA1c, OGTT and random plasma glucose with 3 to 12 months interval. Seven-day continuous glucose monitoring (CGM) was performed on an age and sex-matched cohort. We showed that rising HbA1c, impaired glucose tolerance in OGTT, random plasma glucose values of ≥7.8mmol/l and potentially CGM can predict type 1 diabetes with a median time to diagnosis of approximately one year. Our results suggest that especially HbA1c and random plasma glucose are cost-effective and improve the prediction of diabetes. These markers may be useful for monitoring the response to treatment in prevention studies.%%%%TiivistelmaTyypin 1 diabetesta pidetaan T-soluvalitteisena autoimmuunitautina, joka johtaa haiman beetasolujen tuhoutumiseen. Tyypin 1 diabeteksen ennustaminen perustuu talla hetkella diabetekseen assosioituviin vasta-aineisiin, jotka antavat 84% kumulatiivisen riskin 15 vuoden seurannassa. Taudin puhkeamisen ajankohdan ennustaminen on kuitenkin edelleen vaikeaa. Tama vaitoskirja kasittelee glukoosiaineenvaihduntaa vasta-ainepositiivisilla lapsilla, joilla on suurentunut riski sairastua tyypin 1 diabetekseen. Suomalaisessa DIPP-tutkimuksessa vasta-aineiden kehittymista on seurattu yhteensa 14876 lapselta. Seurannan aikana 567 lasta kehitti ≥2 autovasta-ainetta ja naista 255 (45%) sairastui tyypin 1 diabetekseen joulukuun loppuun 2011 mennessa. Glukoosiaineenvaihduntaa seurattiin tutkimalla HbA1c, OGTT ja satunnaisia verensokeriarvoja 3-12 kuukauden valein. Ika ja sukupuolivakioidussa kohortissa tehtiin jatkuvan sokeripitoisuuden seuranta (CGM). Tutkimuksessamme nouseva HbA1c, heikentynyt sokerin sieto OGTT-kokeessa, satunnainen verensokeri ≥7.8 mmol/l ja mahdollisesti CGM ennustavat tyypin 1 diabeteksen puhkeamista. Tulostemme perusteella erityisesti kustannustehokkaat HbA1c ja satunnainen verensokeri parantavat diabeteksen ennustamista. Nama parametrit saattavat olla hyodyllisia myos preventiotutkimuksissa hoitovasteen seurannassa." @default.
- W2546780780 created "2016-11-11" @default.
- W2546780780 creator A5013587373 @default.
- W2546780780 date "2016-01-01" @default.
- W2546780780 modified "2023-09-23" @default.
- W2546780780 title "Glucose metabolism in preclinical type 1 diabetes" @default.
- W2546780780 hasPublicationYear "2016" @default.
- W2546780780 type Work @default.
- W2546780780 sameAs 2546780780 @default.
- W2546780780 citedByCount "2" @default.
- W2546780780 countsByYear W25467807802016 @default.
- W2546780780 crossrefType "journal-article" @default.
- W2546780780 hasAuthorship W2546780780A5013587373 @default.
- W2546780780 hasConcept C126322002 @default.
- W2546780780 hasConcept C134018914 @default.
- W2546780780 hasConcept C159654299 @default.
- W2546780780 hasConcept C163764329 @default.
- W2546780780 hasConcept C203014093 @default.
- W2546780780 hasConcept C2777180221 @default.
- W2546780780 hasConcept C2777451964 @default.
- W2546780780 hasConcept C2781232474 @default.
- W2546780780 hasConcept C555293320 @default.
- W2546780780 hasConcept C71924100 @default.
- W2546780780 hasConcept C72563966 @default.
- W2546780780 hasConceptScore W2546780780C126322002 @default.
- W2546780780 hasConceptScore W2546780780C134018914 @default.
- W2546780780 hasConceptScore W2546780780C159654299 @default.
- W2546780780 hasConceptScore W2546780780C163764329 @default.
- W2546780780 hasConceptScore W2546780780C203014093 @default.
- W2546780780 hasConceptScore W2546780780C2777180221 @default.
- W2546780780 hasConceptScore W2546780780C2777451964 @default.
- W2546780780 hasConceptScore W2546780780C2781232474 @default.
- W2546780780 hasConceptScore W2546780780C555293320 @default.
- W2546780780 hasConceptScore W2546780780C71924100 @default.
- W2546780780 hasConceptScore W2546780780C72563966 @default.
- W2546780780 hasLocation W25467807801 @default.
- W2546780780 hasOpenAccess W2546780780 @default.
- W2546780780 hasPrimaryLocation W25467807801 @default.
- W2546780780 hasRelatedWork W2017164312 @default.
- W2546780780 hasRelatedWork W2036825550 @default.
- W2546780780 hasRelatedWork W2037469380 @default.
- W2546780780 hasRelatedWork W2077088627 @default.
- W2546780780 hasRelatedWork W2084122199 @default.
- W2546780780 hasRelatedWork W2085241786 @default.
- W2546780780 hasRelatedWork W2120189647 @default.
- W2546780780 hasRelatedWork W2167519335 @default.
- W2546780780 hasRelatedWork W2274642909 @default.
- W2546780780 hasRelatedWork W238248181 @default.
- W2546780780 hasRelatedWork W2480518727 @default.
- W2546780780 hasRelatedWork W2774104809 @default.
- W2546780780 hasRelatedWork W2793637425 @default.
- W2546780780 hasRelatedWork W2795223391 @default.
- W2546780780 hasRelatedWork W2921740078 @default.
- W2546780780 hasRelatedWork W2987126160 @default.
- W2546780780 hasRelatedWork W3034640108 @default.
- W2546780780 hasRelatedWork W3183643374 @default.
- W2546780780 hasRelatedWork W3188841440 @default.
- W2546780780 hasRelatedWork W3214219840 @default.
- W2546780780 isParatext "false" @default.
- W2546780780 isRetracted "false" @default.
- W2546780780 magId "2546780780" @default.
- W2546780780 workType "article" @default.