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• W2546789245 abstract "Listeria monocytogenes is a Gram-positive intracellular bacterium that was transmitted through contaminated food and causes sepsis and even death. IL-37 has been described as an important anti-inflammatory factor, but little is known about the function of IL-37 in host defense against Liseria monocytogenes (Lm) infection. In mice model of systemic infection, we found that mice treated with IL-37 were more sensitive to Lm infection compared with PBS-treated mice. This reduced resistance to Lm in IL-37-treated mice is accompanied with increased bacterial burden and liver damage. Serum levels of colony-stimulating factors were decreased in IL-37-treated mice. IL-37 treatment reduced bactericidal ability of bone marrow derived macrophages (BMDMs) in vitro, which contribute to the inability of IL-37-treated mice to combat Lm infection. Furthermore, increased apoptosis was observed in Lm-infected macrophages treated with IL-37. Increased macrophage apoptosis reduced percentage in liver macrophages was observed in IL-37-treated mice following Lm infection. These results indicate the negative regulatory effect of IL-37 on host resistance during immune defense against Lm." @default.
• W2546789245 created "2016-11-11" @default.
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• W2546789245 date "2017-04-01" @default.
• W2546789245 modified "2023-10-16" @default.
• W2546789245 title "IL-37 impairs host resistance to Listeria infection by suppressing macrophage function" @default.
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• W2546789245 doi "https://doi.org/10.1016/j.bbrc.2016.11.002" @default.
• W2546789245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27816450" @default.
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