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- W254683514 abstract "T-cell hybridomas specific for the synthetic polypeptide antigen L-glutamic acid/sup 60/-L-alanine/sup 30/-L-tyrosine/sup 10/ (GAT) release TsF spontaneously. Recent studies by Trial et al. have shown however that no more than 10% of the hybridoma cells display TsF or I-J determinants on their cell surface. Addition of interleukin 2 (IL-2) to Ts hybridomas markedly increases the cell surface expression of both I-J and TsF determinants. We have extended these studies to the biosynthesis of TsF by IL-2 treated Ts hybridomas. IL-2 has no effect on the cell growth of these hybridomas and little overall effect is observed on protein biosynthesis. Nevertheless, the addition of IL-2 leads to a substantial increase in TsF production as measured by both bioactivity and by direct analysis of /sup 35/S-methionine incorporation into TsF. Treatment of the TsF producing hybridomas with phorbol myristate acetate (PMA) causes an increase in the level of IL-2 receptor expression in these hybridomas and enhances the effects of IL-2 on the biosynthesis of TsF. These data suggest that in addition to its growth promoting properties, IL-2 may provide a signal that triggers suppressor cells to release antigen specific suppressor factors." @default.
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- W254683514 date "1986-03-01" @default.
- W254683514 modified "2023-09-22" @default.
- W254683514 title "Stimulation by interleukin 2 of antigen-specific suppressor factor biosynthesis in T-suppressor cell hybridomas" @default.
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