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- W2547105280 abstract "Antibody-based treatment of malignancies first noted success in the 1990s with the advent of rituximab, a monoclonal antibody directed against CD20, a transmembrane phosphoprotein expressed on B cells. Brentuximab vedotin (BV) is an ADC with efficacy in CD30-positive malignancies and is composed of an antihuman IgG-1 antibody directed against the transmembrane protein, CD30, conjugated by a protease-cleavable dipeptide linker to the antimicrotubule agent monomethyl auristatin E (MMAE). Hodgkin's lymphoma (HL) is an aggressive B-cell malignancy that arises from germinal center or postgerminal center B cells and is subdivided into two main categories, classical HL or nodular lymphocyte-predominant HL based on the morphological appearance of the malignant cells and their microenvironment. BV exerts its selective effects by binding to the extracellular domain of CD30, undergoing receptor-mediated endocytosis, followed by intracellular conveyance to the lysosome, where the peptide linker is selectively cleaved." @default.
- W2547105280 created "2016-11-11" @default.
- W2547105280 creator A5078705613 @default.
- W2547105280 creator A5081213752 @default.
- W2547105280 date "2016-11-03" @default.
- W2547105280 modified "2023-10-16" @default.
- W2547105280 title "<scp>ADCs</scp> Approved for Use: Brentuximab Vedotin" @default.
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- W2547105280 doi "https://doi.org/10.1002/9781119060727.ch15" @default.
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