Matches in SemOpenAlex for { <https://semopenalex.org/work/W2547120907> ?p ?o ?g. }
- W2547120907 endingPage "2434" @default.
- W2547120907 startingPage "2427" @default.
- W2547120907 abstract "Objective: To characterize a brainstem location specific to coma-causing lesions, and its functional connectivity network. Methods: We compared 12 coma-causing brainstem lesions to 24 control brainstem lesions using voxel-based lesion-symptom mapping in a case-control design to identify a site significantly associated with coma. We next used resting-state functional connectivity from a healthy cohort to identify a network of regions functionally connected to this brainstem site. We further investigated the cortical regions of this network by comparing their spatial topography to that of known networks and by evaluating their functional connectivity in patients with disorders of consciousness. Results: A small region in the rostral dorsolateral pontine tegmentum was significantly associated with coma-causing lesions. In healthy adults, this brainstem site was functionally connected to the ventral anterior insula (AI) and pregenual anterior cingulate cortex (pACC). These cortical areas aligned poorly with previously defined resting-state networks, better matching the distribution of von Economo neurons. Finally, connectivity between the AI and pACC was disrupted in patients with disorders of consciousness, and to a greater degree than other brain networks. Conclusions: Injury to a small region in the pontine tegmentum is significantly associated with coma. This brainstem site is functionally connected to 2 cortical regions, the AI and pACC, which become disconnected in disorders of consciousness. This network of brain regions may have a role in the maintenance of human consciousness." @default.
- W2547120907 created "2016-11-11" @default.
- W2547120907 creator A5010066843 @default.
- W2547120907 creator A5018922279 @default.
- W2547120907 creator A5027042734 @default.
- W2547120907 creator A5034034528 @default.
- W2547120907 creator A5047886911 @default.
- W2547120907 creator A5056623917 @default.
- W2547120907 creator A5061379701 @default.
- W2547120907 creator A5066680883 @default.
- W2547120907 creator A5072188433 @default.
- W2547120907 creator A5077179906 @default.
- W2547120907 creator A5091678814 @default.
- W2547120907 date "2016-11-04" @default.
- W2547120907 modified "2023-10-10" @default.
- W2547120907 title "A human brain network derived from coma-causing brainstem lesions" @default.
- W2547120907 cites W1931427066 @default.
- W2547120907 cites W1965343259 @default.
- W2547120907 cites W1967534613 @default.
- W2547120907 cites W1970695058 @default.
- W2547120907 cites W1975317943 @default.
- W2547120907 cites W1981842242 @default.
- W2547120907 cites W1999359468 @default.
- W2547120907 cites W2002293846 @default.
- W2547120907 cites W2006789534 @default.
- W2547120907 cites W2015458876 @default.
- W2547120907 cites W2016521818 @default.
- W2547120907 cites W2023808115 @default.
- W2547120907 cites W2033881971 @default.
- W2547120907 cites W2035809725 @default.
- W2547120907 cites W2045226019 @default.
- W2547120907 cites W2052196200 @default.
- W2547120907 cites W2054281595 @default.
- W2547120907 cites W2054766674 @default.
- W2547120907 cites W2057011129 @default.
- W2547120907 cites W2057617462 @default.
- W2547120907 cites W2065125613 @default.
- W2547120907 cites W2091108618 @default.
- W2547120907 cites W2094500507 @default.
- W2547120907 cites W2107632000 @default.
- W2547120907 cites W2112652260 @default.
- W2547120907 cites W2116658855 @default.
- W2547120907 cites W2121148760 @default.
- W2547120907 cites W2124088053 @default.
- W2547120907 cites W2138028423 @default.
- W2547120907 cites W2140077363 @default.
- W2547120907 cites W2141447814 @default.
- W2547120907 cites W2147595049 @default.
- W2547120907 cites W2152527426 @default.
- W2547120907 cites W2294553905 @default.
- W2547120907 cites W2307176359 @default.
- W2547120907 cites W2323787234 @default.
- W2547120907 cites W4231960321 @default.
- W2547120907 cites W4242036627 @default.
- W2547120907 cites W4295750005 @default.
- W2547120907 cites W625878222 @default.
- W2547120907 doi "https://doi.org/10.1212/wnl.0000000000003404" @default.
- W2547120907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5177681" @default.
- W2547120907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27815400" @default.
- W2547120907 hasPublicationYear "2016" @default.
- W2547120907 type Work @default.
- W2547120907 sameAs 2547120907 @default.
- W2547120907 citedByCount "166" @default.
- W2547120907 countsByYear W25471209072016 @default.
- W2547120907 countsByYear W25471209072017 @default.
- W2547120907 countsByYear W25471209072018 @default.
- W2547120907 countsByYear W25471209072019 @default.
- W2547120907 countsByYear W25471209072020 @default.
- W2547120907 countsByYear W25471209072021 @default.
- W2547120907 countsByYear W25471209072022 @default.
- W2547120907 countsByYear W25471209072023 @default.
- W2547120907 crossrefType "journal-article" @default.
- W2547120907 hasAuthorship W2547120907A5010066843 @default.
- W2547120907 hasAuthorship W2547120907A5018922279 @default.
- W2547120907 hasAuthorship W2547120907A5027042734 @default.
- W2547120907 hasAuthorship W2547120907A5034034528 @default.
- W2547120907 hasAuthorship W2547120907A5047886911 @default.
- W2547120907 hasAuthorship W2547120907A5056623917 @default.
- W2547120907 hasAuthorship W2547120907A5061379701 @default.
- W2547120907 hasAuthorship W2547120907A5066680883 @default.
- W2547120907 hasAuthorship W2547120907A5072188433 @default.
- W2547120907 hasAuthorship W2547120907A5077179906 @default.
- W2547120907 hasAuthorship W2547120907A5091678814 @default.
- W2547120907 hasBestOaLocation W25471209072 @default.
- W2547120907 hasConcept C100136789 @default.
- W2547120907 hasConcept C104996578 @default.
- W2547120907 hasConcept C120665830 @default.
- W2547120907 hasConcept C121332964 @default.
- W2547120907 hasConcept C141516989 @default.
- W2547120907 hasConcept C142724271 @default.
- W2547120907 hasConcept C15744967 @default.
- W2547120907 hasConcept C169760540 @default.
- W2547120907 hasConcept C186720457 @default.
- W2547120907 hasConcept C24566897 @default.
- W2547120907 hasConcept C2777938509 @default.
- W2547120907 hasConcept C2778170955 @default.
- W2547120907 hasConcept C2781156865 @default.
- W2547120907 hasConcept C3018011982 @default.