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- W2547214876 abstract "The purpose of current investigation is to evaluate the safety and efficacy of galantamine in patients with dementia of various etiologies previously treated with conventional ChEIs and other anitdementia medications. This is a post–hoc analysis of a previously conducted 12–week PMS–type open–label, multi–center trial with Reminyl. Patients had a clinical diagnosis of various dementing illnesses including AD, VaD, mixed dementia (AD + VaD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB). Upon enrollment, all patients were commenced immediately on galantamine treatment (without a washout period). The starting dose was 8mg/day and target doses were reached using a 4–week dose–escalation schedule. Outcome measures Efficacy: Subset items selected from activities of daily living and non–cognitive domain. Overall global changes observed by caregivers were also rated as 1, markedly improved; 2, moderately improved; 3, mildly improved; 4, no changes; 5, aggravated. Safety: Safety evaluations throughout the study were comprised of physical examinations, electorcardiography, vital signs, standard laboratory tests, and monitoring for adverse events (AE). Aberrant motor behavior and anxiety were two most commonly improved subset items after switching medications to galantamine regardless of dementia subtypes. Caregivers's Assessments (global impression change) were rated as markedly improved in 5.6%, moderately improved 27.3%, mildly improved in 40.4%, no changes in 24.5%, and aggravated in 2.2% Adverse events: AEs were markedly improved in 5.6%, moderately improved in 24.9%, mildly improved in 41.4%, no changes in 23.5%, aggravated in 2.223 Suppl A:A13–24." @default.
- W2547214876 created "2016-11-11" @default.
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- W2547214876 date "2006-07-01" @default.
- W2547214876 modified "2023-09-27" @default.
- W2547214876 title "P4-429: Switching to reminyl for good tolerability" @default.
- W2547214876 doi "https://doi.org/10.1016/j.jalz.2006.05.2171" @default.
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