Matches in SemOpenAlex for { <https://semopenalex.org/work/W2547285605> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2547285605 abstract "The goal of project detailed in this paper was to develop a pharmacokinetic compartmental model for describing the complex activity of targeted microbubble (MB) contrast agents used for molecular ultrasound (US) imaging. This imaging study used renal cell carcinoma (RCC)-bearing mice. Either VEGFRR2-targeted or control MBs were intravenously injected. Each animal was imaged before MB injection and for 5 min after using a low-intensity nonlinear imaging mode implemented on a SONIX RP US system (BK Ultrasound) equipped with a L12-4 transducer. After a 4 h delay to allow MB clearance, a subset of animals that received targeted MBs during the first imaging session were reimaged using control MBs and vice versa. Tumors were manually segmented from the US image sequences and a mean intensity value was computed for each frame. A two compartment kinetic model was developed and fit to time-intensity curve (TIC) data. Input parameters for this model include MB dose, tumor size and vascular volume. Output parameters were then estimated using this model that relate to targeted MB binding and clearance. An estimate of fractional tumor vascularity was computed as the percentage of image pixels above a defined intensity threshold compared to the number of pixels for the tumor space. After euthanasia, immunohistologic analysis was performed on excised tumor tissue. The model was in good agreement with TIC data describing targeted MB flow and binding in the tumor vascularity (R2 > 0.89, p 0.77). Overall, the two-compartment model may be useful for describing flow binding kinetics of targeted MBs used during molecular US studies." @default.
- W2547285605 created "2016-11-11" @default.
- W2547285605 creator A5023655473 @default.
- W2547285605 creator A5030191726 @default.
- W2547285605 creator A5048052461 @default.
- W2547285605 date "2016-09-01" @default.
- W2547285605 modified "2023-09-25" @default.
- W2547285605 title "Quantification in molecular ultrasound imaging using compartmental modeling" @default.
- W2547285605 cites W1837482701 @default.
- W2547285605 cites W1838890728 @default.
- W2547285605 cites W1988269116 @default.
- W2547285605 cites W2012146686 @default.
- W2547285605 cites W2047224304 @default.
- W2547285605 cites W2055920303 @default.
- W2547285605 cites W2059023384 @default.
- W2547285605 cites W2065355090 @default.
- W2547285605 cites W2114428020 @default.
- W2547285605 cites W2125227270 @default.
- W2547285605 cites W2135722965 @default.
- W2547285605 cites W2170762615 @default.
- W2547285605 doi "https://doi.org/10.1109/ultsym.2016.7728486" @default.
- W2547285605 hasPublicationYear "2016" @default.
- W2547285605 type Work @default.
- W2547285605 sameAs 2547285605 @default.
- W2547285605 citedByCount "0" @default.
- W2547285605 crossrefType "proceedings-article" @default.
- W2547285605 hasAuthorship W2547285605A5023655473 @default.
- W2547285605 hasAuthorship W2547285605A5030191726 @default.
- W2547285605 hasAuthorship W2547285605A5048052461 @default.
- W2547285605 hasConcept C121332964 @default.
- W2547285605 hasConcept C126838900 @default.
- W2547285605 hasConcept C136229726 @default.
- W2547285605 hasConcept C143753070 @default.
- W2547285605 hasConcept C154945302 @default.
- W2547285605 hasConcept C160633673 @default.
- W2547285605 hasConcept C178596483 @default.
- W2547285605 hasConcept C2989005 @default.
- W2547285605 hasConcept C41008148 @default.
- W2547285605 hasConcept C62520636 @default.
- W2547285605 hasConcept C71924100 @default.
- W2547285605 hasConcept C93038891 @default.
- W2547285605 hasConceptScore W2547285605C121332964 @default.
- W2547285605 hasConceptScore W2547285605C126838900 @default.
- W2547285605 hasConceptScore W2547285605C136229726 @default.
- W2547285605 hasConceptScore W2547285605C143753070 @default.
- W2547285605 hasConceptScore W2547285605C154945302 @default.
- W2547285605 hasConceptScore W2547285605C160633673 @default.
- W2547285605 hasConceptScore W2547285605C178596483 @default.
- W2547285605 hasConceptScore W2547285605C2989005 @default.
- W2547285605 hasConceptScore W2547285605C41008148 @default.
- W2547285605 hasConceptScore W2547285605C62520636 @default.
- W2547285605 hasConceptScore W2547285605C71924100 @default.
- W2547285605 hasConceptScore W2547285605C93038891 @default.
- W2547285605 hasLocation W25472856051 @default.
- W2547285605 hasOpenAccess W2547285605 @default.
- W2547285605 hasPrimaryLocation W25472856051 @default.
- W2547285605 hasRelatedWork W1605177983 @default.
- W2547285605 hasRelatedWork W1916012762 @default.
- W2547285605 hasRelatedWork W2013066561 @default.
- W2547285605 hasRelatedWork W2016820754 @default.
- W2547285605 hasRelatedWork W2024945802 @default.
- W2547285605 hasRelatedWork W2074984570 @default.
- W2547285605 hasRelatedWork W2191706296 @default.
- W2547285605 hasRelatedWork W2242711010 @default.
- W2547285605 hasRelatedWork W2510515547 @default.
- W2547285605 hasRelatedWork W2533537845 @default.
- W2547285605 hasRelatedWork W2537094723 @default.
- W2547285605 hasRelatedWork W2560682235 @default.
- W2547285605 hasRelatedWork W2768437779 @default.
- W2547285605 hasRelatedWork W2769370386 @default.
- W2547285605 hasRelatedWork W2770395717 @default.
- W2547285605 hasRelatedWork W2907701963 @default.
- W2547285605 hasRelatedWork W3004248181 @default.
- W2547285605 hasRelatedWork W3088612231 @default.
- W2547285605 hasRelatedWork W3097492861 @default.
- W2547285605 hasRelatedWork W2394687465 @default.
- W2547285605 isParatext "false" @default.
- W2547285605 isRetracted "false" @default.
- W2547285605 magId "2547285605" @default.
- W2547285605 workType "article" @default.