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- W2547403448 abstract "Human leukocyte antigens (HLA) have been extensively studied as being antigen presenting receptors, but many aspects of their function remain elusive, especially their association with various autoimmune diseases. Here we discuss an illustrative case of the reciprocal relationship between certain HLA-DRB1 alleles and two diseases, rheumatoid arthritis (RA) and pemphigus vulgaris (PV). RA is strongly associated with HLA-DRB1 alleles that encode a five amino acid sequence motif in the 70-74 region of the DR beta chain, called the shared epitope (SE), while PV is associated with the HLA-DRB1*04:02 allele that encodes a different sequence motif in the same region. Interestingly, while HLA-DRB1*04:02 confers susceptibility to PV, this and other alleles that encode the same sequence motif in the 70-74 region of the DR beta chain are protective against RA. Currently, no convincing explanation for this antagonistic effect is present. Here we briefly review the immunology and immunogenetics of both diseases, identify remaining gaps in our understanding of their association with HLA, and propose the possibility that the 70-74 DR beta epitope may contribute to disease risk by mechanisms other than antigen presentation." @default.
- W2547403448 created "2016-11-11" @default.
- W2547403448 creator A5053328220 @default.
- W2547403448 creator A5067279424 @default.
- W2547403448 date "2017-01-01" @default.
- W2547403448 modified "2023-10-10" @default.
- W2547403448 title "A reciprocal HLA-Disease Association in Rheumatoid Arthritis and Pemphigus Vulgaris" @default.
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- W2547403448 doi "https://doi.org/10.2741/4524" @default.
- W2547403448 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5517013" @default.
- W2547403448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27814654" @default.
- W2547403448 hasPublicationYear "2017" @default.
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