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- W2547520900 abstract "Gnaphalium affine has long been used as a vegetable and as a traditional medicine to treat various diseases in East Asia. In this work, the human neutrophil elastase inhibitory activity and anti-inflammatory effects of the lead phytochemicals isolated from G. affine and their effects on respiratory disease agents were evaluated in vitro. Through activity-guided fractionation, eight compounds (1–8) with different scaffolds were isolated from the EtOAc fraction of G. affine extract (GAE). The GAE inhibited LPS-induced NO production with different potencies. The highest potency for the inhibition of NO, iNOS, and pro-inflammatory cytokine production was found in isolated compounds (1–8). A series of isolated compounds demonstrated modest to high inhibition of HNE with IC50 values of 2.3–46.1 µM. In particular, luteolin-4′-O-β-d-(6″-E-caffeoyl)-glucoside (7) showed noncompetitive inhibition kinetics against HNE. The results of this study support the traditional use of polyphenol-rich products in the prevention and treatment of respiratory disease." @default.
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- W2547520900 date "2016-12-01" @default.
- W2547520900 modified "2023-10-16" @default.
- W2547520900 title "The constituent, anti-inflammation, and human neutrophil elastase inhibitory activity of Gnaphalium affine" @default.
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- W2547520900 doi "https://doi.org/10.1016/j.jff.2016.10.018" @default.
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