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- W2547536298 abstract "Arousal's selective effects on cognition go beyond the simple enhancement of emotional stimuli, sometimes enhancing and other times impairing processing of proximal neutral information. Past work shows that arousal impairs encoding of subsequent neutral stimuli regardless of their top-down priority via the engagement of β-adrenoreceptors. In contrast, retrograde amnesia induced by emotional arousal can flip to enhancement when preceding neutral items are prioritized in top-down attention. Whether β-adrenoreceptors also contribute to this retrograde memory enhancement of goal-relevant neutral stimuli is unclear. In this pharmacological study, we administered 40mg of propranolol or 40mg of placebo to healthy young adults to examine whether emotional arousal's bidirectional effects on declarative memory relies on β-adrenoreceptor activation. Following pill intake, participants completed an emotional oddball task in which they were asked to prioritize a neutral object appearing just before an emotional or neutral oddball image within a sequence of 7 neutral objects. Under placebo, emotional oddballs impaired memory for lower priority oddball+1 objects but had no effect on memory for high priority oddball-1 objects. Propranolol blocked this anterograde amnesic effect of arousal. Emotional oddballs also enhanced selective memory trade-offs significantly more in the placebo than drug condition, such that high priority oddball-1 objects were more likely to be remembered at the cost of their corresponding lower priority oddball+1 objects under arousal. Lastly, those who recalled more high priority oddball-1 objects preceding an emotional versus neutral oddball image showed greater increases in salivary alpha-amylase, a biomarker of noradrenergic system activation, across the task. Together these findings suggest that different noradrenergic mechanisms contribute to the anterograde and retrograde mnemonic effects of arousal on proximal neutral memoranda." @default.
- W2547536298 created "2016-11-11" @default.
- W2547536298 creator A5032666143 @default.
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- W2547536298 creator A5046406175 @default.
- W2547536298 creator A5048563939 @default.
- W2547536298 creator A5048937263 @default.
- W2547536298 date "2017-01-01" @default.
- W2547536298 modified "2023-09-23" @default.
- W2547536298 title "Noradrenergic mechanisms of arousal’s bidirectional effects on episodic memory" @default.
- W2547536298 cites W1577271808 @default.
- W2547536298 cites W1780881577 @default.
- W2547536298 cites W1946221859 @default.
- W2547536298 cites W1954301870 @default.
- W2547536298 cites W1966399026 @default.
- W2547536298 cites W1971046124 @default.
- W2547536298 cites W1976598983 @default.
- W2547536298 cites W1981117292 @default.
- W2547536298 cites W1982137323 @default.
- W2547536298 cites W1985339809 @default.
- W2547536298 cites W1985919273 @default.
- W2547536298 cites W1987344783 @default.
- W2547536298 cites W1989439371 @default.
- W2547536298 cites W1993208680 @default.
- W2547536298 cites W2002072526 @default.
- W2547536298 cites W2002523262 @default.
- W2547536298 cites W2002765466 @default.
- W2547536298 cites W2007311340 @default.
- W2547536298 cites W2010031803 @default.
- W2547536298 cites W2012804469 @default.
- W2547536298 cites W2015509669 @default.
- W2547536298 cites W2017481703 @default.
- W2547536298 cites W2023288808 @default.
- W2547536298 cites W2023648659 @default.
- W2547536298 cites W2027970772 @default.
- W2547536298 cites W2032416844 @default.
- W2547536298 cites W2039236689 @default.
- W2547536298 cites W2045522459 @default.
- W2547536298 cites W2047292580 @default.
- W2547536298 cites W2051526875 @default.
- W2547536298 cites W2051919341 @default.
- W2547536298 cites W2053839006 @default.
- W2547536298 cites W2057079330 @default.
- W2547536298 cites W2061145288 @default.
- W2547536298 cites W2070558705 @default.
- W2547536298 cites W2074441037 @default.
- W2547536298 cites W2076947415 @default.
- W2547536298 cites W2077689316 @default.
- W2547536298 cites W2078445602 @default.
- W2547536298 cites W2078599937 @default.
- W2547536298 cites W2079574859 @default.
- W2547536298 cites W2083074748 @default.
- W2547536298 cites W2083956595 @default.
- W2547536298 cites W2091413411 @default.
- W2547536298 cites W2104643304 @default.
- W2547536298 cites W2104802716 @default.
- W2547536298 cites W2109558179 @default.
- W2547536298 cites W2109661582 @default.
- W2547536298 cites W2110745711 @default.
- W2547536298 cites W2111745829 @default.
- W2547536298 cites W2111968444 @default.
- W2547536298 cites W2112778345 @default.
- W2547536298 cites W2115095583 @default.
- W2547536298 cites W2115194351 @default.
- W2547536298 cites W2118615399 @default.
- W2547536298 cites W2118909914 @default.
- W2547536298 cites W2119314959 @default.
- W2547536298 cites W2124109469 @default.
- W2547536298 cites W2126189390 @default.
- W2547536298 cites W2126712529 @default.
- W2547536298 cites W2129928127 @default.
- W2547536298 cites W2131221832 @default.
- W2547536298 cites W2136267667 @default.
- W2547536298 cites W2138931746 @default.
- W2547536298 cites W2141480009 @default.
- W2547536298 cites W2141498640 @default.
- W2547536298 cites W2143683595 @default.
- W2547536298 cites W2145158408 @default.
- W2547536298 cites W2145419885 @default.
- W2547536298 cites W2145661991 @default.
- W2547536298 cites W2147370971 @default.
- W2547536298 cites W2148716279 @default.
- W2547536298 cites W2148905283 @default.
- W2547536298 cites W2149985837 @default.
- W2547536298 cites W2151488696 @default.
- W2547536298 cites W2153491397 @default.
- W2547536298 cites W2155073651 @default.
- W2547536298 cites W2155380400 @default.
- W2547536298 cites W2156241651 @default.
- W2547536298 cites W2156322511 @default.
- W2547536298 cites W2156984202 @default.
- W2547536298 cites W2157643754 @default.
- W2547536298 cites W2163520994 @default.
- W2547536298 cites W2163862079 @default.
- W2547536298 cites W2167092044 @default.
- W2547536298 cites W2169401493 @default.
- W2547536298 cites W4249467711 @default.
- W2547536298 cites W4252938237 @default.