FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2547580682> ?p ?o ?g. }

• W2547580682 endingPage "319" @default.
• W2547580682 startingPage "310" @default.
• W2547580682 abstract "Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) undergoes numerous post-translational modifications, which impart new function and influence intracellular location. For example, atypical PKC ι/λ phosphorylates GAPDH that locates to vesicular tubular clusters and is required for retrograde membrane trafficking in the early secretory pathway. GAPDH is also required in the endocytic pathway; substitution of Pro234 to Ser (Pro234Ser) rendered CHO cells defective in endocytosis. To determine if GAPDH (Pro234Ser) could inhibit endoplasmic reticulum to Golgi trafficking, we introduced the recombinant mutant enzyme into several biochemical and morphological transport assays. The mutant protein efficiently blocked vesicular stomatitis virus-G protein transport. Because GAPDH binds to microtubules (MTs), we evaluated MT binding and MT intracellular distribution in the presence of the mutant. Although these properties were not changed relative to wild-type, GAPDH (Pro234Ser) altered Golgi complex morphology. We determined that the GAPDH point mutation disrupted association between the enzyme and the serine/threonine kinase Akt. Interestingly Rab1, which functions in anterograde-directed trafficking, stimulates GAPDH-Akt association with membranes in a quantitative binding assay. In contrast, Rab2 does not stimulate GAPDH-Akt membrane binding but instead recruits GAPDH-aPKC. We propose a mechanism whereby the association of GAPDH with Akt or with aPKC serves as a switch to discriminate between anterograde directed cargo and recycling cargo retrieved back to the ER, respectively." @default.
• W2547580682 created "2016-11-11" @default.
• W2547580682 creator A5037148808 @default.
• W2547580682 creator A5053608387 @default.
• W2547580682 creator A5057279048 @default.
• W2547580682 creator A5061438758 @default.
• W2547580682 date "2016-12-01" @default.
• W2547580682 modified "2023-10-15" @default.
• W2547580682 title "GAPDH binds Akt to facilitate cargo transport in the early secretory pathway" @default.
• W2547580682 cites W1152255386 @default.
• W2547580682 cites W1431349848 @default.
• W2547580682 cites W1492038278 @default.
• W2547580682 cites W189263682 @default.
• W2547580682 cites W1913862483 @default.
• W2547580682 cites W1963573377 @default.
• W2547580682 cites W1964802617 @default.
• W2547580682 cites W1965260691 @default.
• W2547580682 cites W1970689030 @default.
• W2547580682 cites W1973945485 @default.
• W2547580682 cites W1977146061 @default.
• W2547580682 cites W1984621921 @default.
• W2547580682 cites W1993179214 @default.
• W2547580682 cites W1996478420 @default.
• W2547580682 cites W1996571155 @default.
• W2547580682 cites W2004779634 @default.
• W2547580682 cites W2006294471 @default.
• W2547580682 cites W2012279551 @default.
• W2547580682 cites W2012679964 @default.
• W2547580682 cites W2013774412 @default.
• W2547580682 cites W2017902030 @default.
• W2547580682 cites W2022005587 @default.
• W2547580682 cites W2023153759 @default.
• W2547580682 cites W2023366803 @default.
• W2547580682 cites W2024149807 @default.
• W2547580682 cites W2028465243 @default.
• W2547580682 cites W2039692456 @default.
• W2547580682 cites W2049524204 @default.
• W2547580682 cites W2051124098 @default.
• W2547580682 cites W2054777631 @default.
• W2547580682 cites W2057619903 @default.
• W2547580682 cites W2057720246 @default.
• W2547580682 cites W2058125945 @default.
• W2547580682 cites W2059571622 @default.
• W2547580682 cites W2060284302 @default.
• W2547580682 cites W2066374288 @default.
• W2547580682 cites W2071792089 @default.
• W2547580682 cites W2076854292 @default.
• W2547580682 cites W2076924960 @default.
• W2547580682 cites W2079638218 @default.
• W2547580682 cites W2084146928 @default.
• W2547580682 cites W2085101416 @default.
• W2547580682 cites W2087661112 @default.
• W2547580682 cites W2094152798 @default.
• W2547580682 cites W2096871163 @default.
• W2547580682 cites W2104572704 @default.
• W2547580682 cites W2105267309 @default.
• W2547580682 cites W2107917574 @default.
• W2547580682 cites W2113617470 @default.
• W2547580682 cites W2115732796 @default.
• W2547580682 cites W2118044204 @default.
• W2547580682 cites W2119914706 @default.
• W2547580682 cites W2123090385 @default.
• W2547580682 cites W2124432707 @default.
• W2547580682 cites W2139503567 @default.
• W2547580682 cites W2152741987 @default.
• W2547580682 cites W2155951732 @default.
• W2547580682 cites W2158133029 @default.
• W2547580682 cites W2191370645 @default.
• W2547580682 cites W2406181473 @default.
• W2547580682 cites W4211214945 @default.
• W2547580682 doi "https://doi.org/10.1016/j.yexcr.2016.10.025" @default.
• W2547580682 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5129630" @default.
• W2547580682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27818247" @default.
• W2547580682 hasPublicationYear "2016" @default.
• W2547580682 type Work @default.
• W2547580682 sameAs 2547580682 @default.
• W2547580682 citedByCount "16" @default.
• W2547580682 countsByYear W25475806822017 @default.
• W2547580682 countsByYear W25475806822018 @default.
• W2547580682 countsByYear W25475806822019 @default.
• W2547580682 countsByYear W25475806822020 @default.
• W2547580682 countsByYear W25475806822021 @default.
• W2547580682 countsByYear W25475806822022 @default.
• W2547580682 countsByYear W25475806822023 @default.
• W2547580682 crossrefType "journal-article" @default.
• W2547580682 hasAuthorship W2547580682A5037148808 @default.
• W2547580682 hasAuthorship W2547580682A5053608387 @default.
• W2547580682 hasAuthorship W2547580682A5057279048 @default.
• W2547580682 hasAuthorship W2547580682A5061438758 @default.
• W2547580682 hasBestOaLocation W25475806822 @default.
• W2547580682 hasConcept C119062480 @default.
• W2547580682 hasConcept C11960822 @default.
• W2547580682 hasConcept C134792803 @default.
• W2547580682 hasConcept C1491633281 @default.
• W2547580682 hasConcept C158617107 @default.
• W2547580682 hasConcept C175969161 @default.
• W2547580682 hasConcept C181199279 @default.
• W2547580682 hasConcept C2776317432 @default.

• next