FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2547625788> ?p ?o ?g. }

• W2547625788 endingPage "754" @default.
• W2547625788 startingPage "747" @default.
• W2547625788 abstract "Alterations in the hypothalamic-pituitary-thyroid axis have been reported following growth hormone (GH) replacement. The aim was to examine the relationship between changes in serum concentration of thyroid hormones and deiodinase activity in subcutaneous adipose tissue, before and after GH replacement.A prospective, observational study of patients receiving GH replacement as part of routine clinical care.Twenty adult hypopituitary men.Serum TSH, thyroid hormones - free and total thyroxine (T4) and triiodothyronine (T3) and reverse T3, thyroglobulin and thyroid-binding globulin (TBG) levels were measured before and after GH substitution. Changes in serum hormone levels were compared to the activity of deiodinase isoenzymes (DIO1, DIO2 and DIO3) in subcutaneous adipose tissue.The mean daily dose of growth hormone (GH) was 0·34 ± 0·11 mg (range 0·15-0·5 mg). Following GH replacement, mean free T4 levels declined (-1·09 ± 1·99 pmol/l, P = 0·02). Reverse T3 levels also fell (-3·44 ± 1·42 ng/dl, P = 0·03) and free T3 levels increased significantly (+0·34 ± 0·15 pmol/l, P = 0·03). In subcutaneous fat, DIO2 enzyme activity declined; DIO1 and DIO3 activities remained unchanged following GH substitution. Serum TSH, thyroglobulin and TBG levels were unaltered by GH therapy.In vitro analysis of subcutaneous adipose tissue from hypopituitary human subjects demonstrates that GH replacement is associated with significant changes in deiodinase isoenzyme activity. However, the observed variation in enzyme activity does not explain the changes in the circulating concentration of thyroid hormones induced by GH replacement. It is possible that deiodinase isoenzymes are differentially regulated by GH in other tissues including liver and muscle." @default.
• W2547625788 created "2016-11-11" @default.
• W2547625788 creator A5015465800 @default.
• W2547625788 creator A5026330260 @default.
• W2547625788 creator A5028107472 @default.
• W2547625788 creator A5028119411 @default.
• W2547625788 creator A5036590392 @default.
• W2547625788 creator A5042061862 @default.
• W2547625788 creator A5042856908 @default.
• W2547625788 creator A5050120092 @default.
• W2547625788 creator A5052511654 @default.
• W2547625788 creator A5058511333 @default.
• W2547625788 creator A5071309763 @default.
• W2547625788 creator A5076041078 @default.
• W2547625788 creator A5081267484 @default.
• W2547625788 date "2016-12-19" @default.
• W2547625788 modified "2023-10-15" @default.
• W2547625788 title "The effect of growth hormone replacement on the thyroid axis in patients with hypopituitarism:<i>in vivo</i>and<i>ex vivo</i>studies" @default.
• W2547625788 cites W1552278202 @default.
• W2547625788 cites W1749693432 @default.
• W2547625788 cites W1966817244 @default.
• W2547625788 cites W1966895214 @default.
• W2547625788 cites W1972651008 @default.
• W2547625788 cites W1973357670 @default.
• W2547625788 cites W1999524014 @default.
• W2547625788 cites W1999848620 @default.
• W2547625788 cites W2006807145 @default.
• W2547625788 cites W2007272731 @default.
• W2547625788 cites W2019116234 @default.
• W2547625788 cites W2020561294 @default.
• W2547625788 cites W2021985236 @default.
• W2547625788 cites W2027421501 @default.
• W2547625788 cites W2049543211 @default.
• W2547625788 cites W2049942469 @default.
• W2547625788 cites W2061792669 @default.
• W2547625788 cites W2080444985 @default.
• W2547625788 cites W2104878795 @default.
• W2547625788 cites W2112897084 @default.
• W2547625788 cites W2117286082 @default.
• W2547625788 cites W2130988832 @default.
• W2547625788 cites W2144425974 @default.
• W2547625788 cites W2151163528 @default.
• W2547625788 cites W2164597303 @default.
• W2547625788 cites W2327980237 @default.
• W2547625788 doi "https://doi.org/10.1111/cen.13272" @default.
• W2547625788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27809356" @default.
• W2547625788 hasPublicationYear "2016" @default.
• W2547625788 type Work @default.
• W2547625788 sameAs 2547625788 @default.
• W2547625788 citedByCount "21" @default.
• W2547625788 countsByYear W25476257882017 @default.
• W2547625788 countsByYear W25476257882018 @default.
• W2547625788 countsByYear W25476257882019 @default.
• W2547625788 countsByYear W25476257882020 @default.
• W2547625788 countsByYear W25476257882021 @default.
• W2547625788 countsByYear W25476257882022 @default.
• W2547625788 countsByYear W25476257882023 @default.
• W2547625788 crossrefType "journal-article" @default.
• W2547625788 hasAuthorship W2547625788A5015465800 @default.
• W2547625788 hasAuthorship W2547625788A5026330260 @default.
• W2547625788 hasAuthorship W2547625788A5028107472 @default.
• W2547625788 hasAuthorship W2547625788A5028119411 @default.
• W2547625788 hasAuthorship W2547625788A5036590392 @default.
• W2547625788 hasAuthorship W2547625788A5042061862 @default.
• W2547625788 hasAuthorship W2547625788A5042856908 @default.
• W2547625788 hasAuthorship W2547625788A5050120092 @default.
• W2547625788 hasAuthorship W2547625788A5052511654 @default.
• W2547625788 hasAuthorship W2547625788A5058511333 @default.
• W2547625788 hasAuthorship W2547625788A5071309763 @default.
• W2547625788 hasAuthorship W2547625788A5076041078 @default.
• W2547625788 hasAuthorship W2547625788A5081267484 @default.
• W2547625788 hasConcept C126322002 @default.
• W2547625788 hasConcept C134018914 @default.
• W2547625788 hasConcept C171089720 @default.
• W2547625788 hasConcept C171269688 @default.
• W2547625788 hasConcept C185592680 @default.
• W2547625788 hasConcept C2776515397 @default.
• W2547625788 hasConcept C2778288131 @default.
• W2547625788 hasConcept C2778417266 @default.
• W2547625788 hasConcept C2778491484 @default.
• W2547625788 hasConcept C2778835679 @default.
• W2547625788 hasConcept C526584372 @default.
• W2547625788 hasConcept C71315377 @default.
• W2547625788 hasConcept C71924100 @default.
• W2547625788 hasConcept C86803240 @default.
• W2547625788 hasConceptScore W2547625788C126322002 @default.
• W2547625788 hasConceptScore W2547625788C134018914 @default.
• W2547625788 hasConceptScore W2547625788C171089720 @default.
• W2547625788 hasConceptScore W2547625788C171269688 @default.
• W2547625788 hasConceptScore W2547625788C185592680 @default.
• W2547625788 hasConceptScore W2547625788C2776515397 @default.
• W2547625788 hasConceptScore W2547625788C2778288131 @default.
• W2547625788 hasConceptScore W2547625788C2778417266 @default.
• W2547625788 hasConceptScore W2547625788C2778491484 @default.
• W2547625788 hasConceptScore W2547625788C2778835679 @default.
• W2547625788 hasConceptScore W2547625788C526584372 @default.
• W2547625788 hasConceptScore W2547625788C71315377 @default.
• W2547625788 hasConceptScore W2547625788C71924100 @default.

• next