FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2547676815> ?p ?o ?g. }

• W2547676815 abstract "Excessive and uncontrollable worry is a defining feature of Generalized Anxiety Disorder. An important endeavor in the treatment of pathological worry is to understand why some people are unable to stop worrying once they have started. Worry perseveration is associated with a tendency to deploy goal-directed worry rules (known as ‘as many as can’ worry rules; AMA). These require attention to the goal of the worry task and continuation of worry until the aims of the ‘worry bout’ are achieved. This study examined the association between the tendency to use AMA worry rules and neural and autonomic responses to a perseverative cognition induction. To differentiate processes underlying AMA worry rule use from trait worry, we also examined the relationship between scores on the Penn State Worry Questionnaire and neural and autonomic responses following the same induction. We used resting-state functional magnetic resonance brain imaging while measuring emotional bodily arousal from heart rate variability (where decreased HRV indicates stress-related parasympathetic withdrawal) in 19 patients with GAD and 21 control participants. Seed-based analyses were conducted to quantify brain changes in functional connectivity with the amygdala. The tendency to adopt an AMA worry rule was associated with validated measures of worry, anxiety, depression, and rumination. AMA worry rule endorsement predicted a stronger decrease in HRV and was positively associated with increased connectivity between right amygdala and locus coeruleus, a brainstem noradrenergic projection nucleus. Higher AMA scores were also associated with increased connectivity between amygdala and rostral superior frontal gyrus. Higher PSWQ scores amplified decreases in functional connectivity between right amygdala and subcallosal cortex, bilateral inferior frontal gyrus, middle frontal gyrus, and areas of parietal cortex. Our results identify neural mechanisms underlying the deployment of AMA worry rules. We propose that the relationship between AMA worry rules and increased connectivity between the amygdala and prefrontal cortex represents attempts by high worriers to maintain arousal and distress levels in order to feel prepared for future threats. Furthermore, we suggest that neural mechanisms associated with the PSWQ represent effortful inhibitory control during worry. These findings provide unique information about the neurobiological processes that underpin worry perseveration." @default.
• W2547676815 created "2016-11-11" @default.
• W2547676815 creator A5021821604 @default.
• W2547676815 creator A5050297916 @default.
• W2547676815 creator A5054846200 @default.
• W2547676815 creator A5067937717 @default.
• W2547676815 creator A5082935440 @default.
• W2547676815 creator A5086912687 @default.
• W2547676815 creator A5087074823 @default.
• W2547676815 date "2016-11-02" @default.
• W2547676815 modified "2023-09-29" @default.
• W2547676815 title "Goal Directed Worry Rules Are Associated with Distinct Patterns of Amygdala Functional Connectivity and Vagal Modulation during Perseverative Cognition" @default.
• W2547676815 cites W1591510841 @default.
• W2547676815 cites W1748454722 @default.
• W2547676815 cites W1760829075 @default.
• W2547676815 cites W1864952092 @default.
• W2547676815 cites W1968923318 @default.
• W2547676815 cites W1969174130 @default.
• W2547676815 cites W1970172133 @default.
• W2547676815 cites W1974080659 @default.
• W2547676815 cites W1984489485 @default.
• W2547676815 cites W1989652160 @default.
• W2547676815 cites W1991745836 @default.
• W2547676815 cites W2001866454 @default.
• W2547676815 cites W2002545763 @default.
• W2547676815 cites W2009494091 @default.
• W2547676815 cites W2011056418 @default.
• W2547676815 cites W2026506811 @default.
• W2547676815 cites W2030679377 @default.
• W2547676815 cites W2032958479 @default.
• W2547676815 cites W2035081813 @default.
• W2547676815 cites W2037676746 @default.
• W2547676815 cites W2037840912 @default.
• W2547676815 cites W2039763524 @default.
• W2547676815 cites W2040909833 @default.
• W2547676815 cites W2058046532 @default.
• W2547676815 cites W2064652878 @default.
• W2547676815 cites W2067486979 @default.
• W2547676815 cites W2070381818 @default.
• W2547676815 cites W2076763018 @default.
• W2547676815 cites W2084863906 @default.
• W2547676815 cites W2086282937 @default.
• W2547676815 cites W2102748276 @default.
• W2547676815 cites W2106089606 @default.
• W2547676815 cites W2106405026 @default.
• W2547676815 cites W2118140362 @default.
• W2547676815 cites W2124526585 @default.
• W2547676815 cites W2125566957 @default.
• W2547676815 cites W2125823313 @default.
• W2547676815 cites W2131197337 @default.
• W2547676815 cites W2136449688 @default.
• W2547676815 cites W2138219516 @default.
• W2547676815 cites W2143859454 @default.
• W2547676815 cites W2146702163 @default.
• W2547676815 cites W2146828510 @default.
• W2547676815 cites W2157649206 @default.
• W2547676815 cites W2286803806 @default.
• W2547676815 cites W2318394495 @default.
• W2547676815 cites W2409629706 @default.
• W2547676815 cites W2465700423 @default.
• W2547676815 cites W4237279138 @default.
• W2547676815 cites W4247665917 @default.
• W2547676815 cites W4249412541 @default.
• W2547676815 doi "https://doi.org/10.3389/fnhum.2016.00553" @default.
• W2547676815 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5089972" @default.
• W2547676815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27853428" @default.
• W2547676815 hasPublicationYear "2016" @default.
• W2547676815 type Work @default.
• W2547676815 sameAs 2547676815 @default.
• W2547676815 citedByCount "22" @default.
• W2547676815 countsByYear W25476768152017 @default.
• W2547676815 countsByYear W25476768152018 @default.
• W2547676815 countsByYear W25476768152019 @default.
• W2547676815 countsByYear W25476768152020 @default.
• W2547676815 countsByYear W25476768152021 @default.
• W2547676815 countsByYear W25476768152022 @default.
• W2547676815 countsByYear W25476768152023 @default.
• W2547676815 crossrefType "journal-article" @default.
• W2547676815 hasAuthorship W2547676815A5021821604 @default.
• W2547676815 hasAuthorship W2547676815A5050297916 @default.
• W2547676815 hasAuthorship W2547676815A5054846200 @default.
• W2547676815 hasAuthorship W2547676815A5067937717 @default.
• W2547676815 hasAuthorship W2547676815A5082935440 @default.
• W2547676815 hasAuthorship W2547676815A5086912687 @default.
• W2547676815 hasAuthorship W2547676815A5087074823 @default.
• W2547676815 hasBestOaLocation W25476768151 @default.
• W2547676815 hasConcept C118552586 @default.
• W2547676815 hasConcept C138496976 @default.
• W2547676815 hasConcept C15744967 @default.
• W2547676815 hasConcept C169760540 @default.
• W2547676815 hasConcept C169900460 @default.
• W2547676815 hasConcept C180747234 @default.
• W2547676815 hasConcept C2776060345 @default.
• W2547676815 hasConcept C2779144063 @default.
• W2547676815 hasConcept C2779226451 @default.
• W2547676815 hasConcept C2779911313 @default.
• W2547676815 hasConcept C2779978724 @default.
• W2547676815 hasConcept C36951298 @default.
• W2547676815 hasConcept C558461103 @default.
• W2547676815 hasConcept C70410870 @default.

• next