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- W2547705738 abstract "Splenic marginal zone lymphoma (SMZL) is an indolent small B-cell lymphoma involving the spleen and bone marrow characterized by a micronodular tumoral infiltration that replaces the preexisting lymphoid follicles and shows marginal zone differentiation as a distinctive finding. SMZL cases are characterized by prominent splenomegaly and bone marrow and peripheral blood infiltration. Cells in peripheral blood show a villous cytology. Bone marrow and peripheral blood characteristic features usually allow a diagnosis of SMZL to be performed. Mutational spectrum of SMZL identifies specific findings, such as 7q loss and NOTCH2 and KLF2 mutations, both genes related with marginal zone differentiation. There is a striking clinical variability in SMZL cases, dependent of the tumoral load and performance status. Specific molecular markers such as 7q loss, p53 loss/mutation, NOTCH2 and KLF2 mutations have been found to be associated with the clinical variability. Distinction from Monoclonal B-cell lymphocytosis with marginal zone phenotype is still an open issue that requires identification of precise and specific thresholds with clinical meaning." @default.
- W2547705738 created "2016-11-11" @default.
- W2547705738 creator A5001399518 @default.
- W2547705738 creator A5041293621 @default.
- W2547705738 creator A5082930849 @default.
- W2547705738 date "2017-03-01" @default.
- W2547705738 modified "2023-09-30" @default.
- W2547705738 title "Splenic marginal zone lymphoma" @default.
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- W2547705738 doi "https://doi.org/10.1016/j.beha.2016.09.005" @default.
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