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- W2547829213 abstract "Background: Chronic urticaria (CU) is a common problem and negatively affects both work and social life because of its chronic relapsing course and poor response to therapy. Conventional therapies of CU sometimes fail to control the disease activity, especially in autologous serum skin test (ASST) +ve patients. More recent therapies that target the immune system are frequently limited by their high cost and/or aggressive side effects. Several lines of evidence have shown a possible therapeutic value of autologous serum therapy (AST) injection in the treatment of recalcitrant CU. Objective: to evaluate the effect of autologous serum therapy in the treatment of CU patients with positive ASST Methods: Our study is a randomized placebo-controlled, single-blind trial. 30 patients were given AST and 30 patients were given IM injection of normal saline (placebo). Both groups received the injections for 9weeks then were followed up 12 weeks after the last injection. Urticaria activity score (UAS-7) and German version of Chronic Urticaria Quality of Life Questionnaire (CU-Q (2)oL) were used to evaluate the effectiveness of therapy Results: we demonstrated a statistically significant improvement in UAS-7 score and (CU-Q(2)oL) Questionnaire in cases group after 9 weeks and after 12 weeks from last injection Conclusion: The autologous serum therapy might prove to be a potent and probably curative treatment option" @default.
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- W2547829213 date "2015-01-01" @default.
- W2547829213 modified "2023-09-23" @default.
- W2547829213 title "Efficacy of Autologous Serum Therapy in Patients with Recalcitrant Chronic Urticaria and Positive Autologous Serum Skin Test" @default.
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