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- W2547888907 abstract "AJAYI, S. A.; AZU, O. O.; CHUTURGOON, A.; PHULUKDAREE, A.; KOMOLAFE, O. A. & OFUSORI, D. A. Comparison ofantioxidant effects of Kolaviron and Vitamin c interventions on testicular structures following Nevirapine administration in Sprague-Dawley rats. Int. J. Morphol., 34(1):102-109, 2016.SUMMARY: Testicular toxicity has been implicated in highly active anti-retroviral therapy (HAART) treatment. Hence there isneed to identify an effective antioxidant product that can alleviate testicular necrosis due to HAART administration. Forty eight adultmale Sprague-Dawley rats were used in this study. The animals were divided into eight (8) groups: A-H (n= 6). Group A animals r eceivednormal saline as the control; Group B was given Nevirapine (Nv); Group C was given Kolaviron (Kv); Group D was given vitamin C;Group E was given Nv and Kv; Group F was given Nv and Vitamin C; Group G was given Nv for 56 d and Kv for 28 d serving as awithdrawal group; Group H was given corn oil. Nv, Kv and Vit. C were given at 1.54, 200 and 250 (mg·kg)/bw respectively while alladministrations were through oral gavage. The body weights were taken every other day. Thereafter, they were anaesthetized withhalothane. The testes were excised, weighed, fixed in Bouin’s fluid and stained with HE Kolaviron; Testicular toxicity; Sperm count; Antioxidant enzymes." @default.
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- W2547888907 title "Comparison of Antioxidant Effects of Kolaviron and Vitamin C Interventions on Testicular Structures Following Nevirapine Administration in Sprague-Dawley Rats Comparación de los Efectos Antioxidantes en la Intervención con Kolaviron y Vitamina C sobre las Estructuras Testiculares Después de la Administración de Nevirapina en Ratas Sprague-Dawley" @default.
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