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- W2547943944 abstract "Clinically biological activity is the result of a chemical compound’s interaction with a human organism. The biological activity is dependent upon the compound’s structure and its physical-chemical characteristics, as well as the biological entity and its mode of therapeutic treatment. Pyrazoles are unique in their chemical behavior not only among heterocyclic compounds in general, but also among related azoles. This is because pyrazole possesses the typical properties of the aromatic system, which are in fact rather pronounced in these derivatives, together with the high liability of the ring under certain condition. Pyrazole un substituted in 1position show NHacidity. The pKa value of Pyrazole is 14.21 and equal to that of imidazole. Now a day’s vast numbers of compounds with pyrazole nucleus have been reported to show a broad spectrum of biological activity includingantimicrobial, anti-cyclooxygenase, anticonvulsant, antitubercular, antitumor, antiinflammatory, analgesic, antidiabetic, antipshycotic etc. Since most of thepyrazole derivatives show antimicrobial activity, the synthesized compounds are also expected to show anti-microbial activity. Hence, our plan is to synthesize some substituted pyrazole derivatives and subsequently screen for their antimicrobial activity. METHODS AND METERIALS Melting points were recorded on an X4-Data microscopic melting point apparatus and are uncorrected. The IR spectra of the compounds were recorded on SHIMADZU FT-IR8400S with KBr Pellets. H-NMR spectra were recorded on JNM-ECS400, 400 MHz.The chemical shifts are reported as parts per million down fields from tetramethylsilane (TMS). Mass spectra were recorded on LC–MS 2010A SHIMADZU instrument. The elemental analyses were performed on a EuroERElemental Analyser.The purity of the compounds was checked by TLC on precoatedsilica gel G (E Merck)." @default.
- W2547943944 created "2016-11-11" @default.
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- W2547943944 date "2015-01-01" @default.
- W2547943944 modified "2023-09-24" @default.
- W2547943944 title "SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL EVALUATION OF PYRAZOLE DERIVATIVES" @default.
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